Document Detail


Allergy to murine antigens in a biological research institute.
MedLine Citation:
PMID:  7288048     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Symptomatic and immunologic responses to allergens from laboratory mice were studied in a research institute. Subjects who had been exposed to mice and 50 unexposed subjects were studied by questionnaire and by prick tests with seven prevalent aeroallergens and allergens from mouse urine and pelts. Of the 121 exposed subjects, 39 (32.2%) had respiratory, ocular, or cutaneous symptoms after exposure to mice; occurrence of these symptoms correlated with positive skin tests to purified mouse urinary proteins (MUP) and pelt allergens from CBA/H mice. Serum levels of IgG antibodies correlated with the frequency of mouse exposure. In subjects with seasonal allergic rhinitis, nasal symptoms from exposure to mice, positive prick tests to MUP, and IgE antibodies to MUP were significantly more prevalent. The possibility of genetic influences on susceptibility to mouse allergy were also suggested by a negative association between the incidence of HLA-DRW6 and positive prick-test responses to urinary proteins from C57BL and BALB/c mice among the 54 subjects who were exposed to mice and tested for DR locus antigens (p = 0.05). However, no significant differences in any of the loci studied could be shown in subjects with and without nasal symptoms from exposure to mice.
Authors:
M J Schumacher; B D Tait; M C Holmes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  68     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1981-12-22     Completed Date:  1981-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  310-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Academic Medical Centers*
Animals
Antibody Specificity
Antigens*
Female
HLA Antigens
Humans
Hypersensitivity / immunology*
Immunoglobulin E / biosynthesis
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred CBA
Molecular Weight
Proteinuria / immunology
Rhinitis, Allergic, Seasonal / immunology
Skin Tests
Time Factors
Chemical
Reg. No./Substance:
0/Antigens; 0/HLA Antigens; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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