Document Detail


Allergy to kiwi in patients with baker's asthma: identification of potential cross-reactive allergens.
MedLine Citation:
PMID:  18727477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Baker's asthma is a frequent IgE-mediated occupational disorder mainly provoked by inhalation of cereal flour. Allergy to kiwifruit has being increasingly reported in the past few years. No association between both allergic disorders has been described so far. METHODS: Twenty patients with occupational asthma caused by wheat flour inhalation were studied. Kiwi allergens Act d 1 and Act d 2 were purified by cation-exchange chromatography. Wheat, rye, and kiwi extracts, purified kiwi allergens, and model plant glycoproteins were analyzed by IgE immunodetection, enzyme-linked immunosorbent assay (ELISA), and inhibition ELISAs. RESULTS: Kiwifruit ingestion elicited oral allergy syndrome in 7 of the 20 patients (35%) with baker's asthma. Positive specific IgE and skin prick test responses to this fruit were found in all these kiwi allergic patients, and IgE to Act d 1 and Act d 2 was detected in 57% and 43%, respectively, of the corresponding sera. Actinidin Act d 1 and bromelain (harboring cross-reactive carbohydrate determinants) reached above 50% inhibition of the IgE binding to wheat and/or kiwi extracts. CONCLUSIONS: A potential association between respiratory allergy to cereal flour and allergy to kiwifruit has been disclosed. Cross-reactive carbohydrate determinants and thiol-proteaseshomologous to Act d 1 are responsible for wheat-kiwi crossreactivity in some patients.
Authors:
Arantxa Palacin; Santiago Quirce; Rosa Sánchez-Monge; Mar Fernández-Nieto; Javier Varela; Joaquín Sastre; Gabriel Salcedo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  101     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-27     Completed Date:  2008-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  200-5     Citation Subset:  IM    
Affiliation:
Unidad de Bioquímica, Departamento de Biotecnología, E.T.S. Ingenieros Agrónomos, UPM, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Actinidia / immunology*
Adult
Allergens / immunology*,  isolation & purification
Amino Acid Sequence
Asthma / etiology,  immunology*
Bromelains / immunology
Cross Reactions
Cysteine Endopeptidases / immunology
Female
Flour
Food Hypersensitivity / immunology*
Humans
Immunoglobulin E / blood
Male
Middle Aged
Molecular Sequence Data
Occupational Diseases / etiology,  immunology*
Plant Proteins / immunology,  isolation & purification
Secale cereale / immunology
Sequence Alignment
Skin Tests
Wheat Hypersensitivity / immunology*
Chemical
Reg. No./Substance:
0/Allergens; 0/Plant Proteins; 37341-29-0/Immunoglobulin E; 9001-00-7/Bromelains; EC 3.4.22.-/Cysteine Endopeptidases; EC 3.4.22.14/actinidain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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