Document Detail


Allergy and the skin.
MedLine Citation:
PMID:  18721326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Allergic skin disorders include urticaria, angioedema, contact dermatitis and atopic dermatitis, but the model fitting most closely the systemic concept of allergy is atopic dermatitis (AD), the pathogenesis of which is linked to a complex interaction between skin barrier dysfunction and environmental factors such as allergens and microbes. In particular, an important advance was the demonstration that the mutation of the skin barrier protein filaggrin is related strictly to allergen sensitization and to the development of asthma in subjects with AD. The altered skin barrier function, caused by several factors, results in the passage of allergens through the skin and to systemic responses. A pivotal role in such a response is exerted by Langerhans cells which, via their immunoglobulin E (IgE) receptor, capture the allergens and present them to T cells. When T helper type 2 (Th2) cells are activated, the production of a proinflammatory cytokines and chemokines pattern sustains the persistence of inflammation. Known AD-related cytokines are interleukin (IL)-5, IL-13 and tumour necrosis factor (TNF)-alpha, with emerging importance for IL-17, which seems to drive airway inflammation following cutaneous exposure to antigens, and IL-31, which is expressed primarily in skin-homing Th2 cells. Skin-homing is another crucial event in AD, mediated by the cutaneous lymphocyte-associated antigens (CLA) receptor, which characterizes T cell subpopulations with different roles in AD and asthma.
Authors:
C Incorvaia; F Frati; N Verna; S D'Alò; A Motolese; S Pucci
Related Documents :
17557146 - Skin-induced tolerance and its reversal by toll-like receptor ligands.
24075516 - Induction of m2-macrophages by tumour cells and tumour growth promotion by m2-macrophag...
1373746 - The state of differentiation of cultured human keratinocytes determines the level of in...
24184156 - Immune responses to viable and degenerative metacestodes of taenia solium in naturally ...
24872326 - Cytotoxic markers associate with protection against malaria in human volunteers immuniz...
15965096 - Cadmium toxicity toward caspase-independent apoptosis through the mitochondria-calcium ...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  153 Suppl 1     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2008-09-24     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  27-9     Citation Subset:  IM    
Affiliation:
Allergy/Pulmonary Rehabilitation Unit, ICP Hospital, Milan, Italy. cristoforo.incorvaia@gmail.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Allergens / immunology
Animals
Cytokines / immunology
Dermatitis, Atopic / immunology*
Humans
Hypersensitivity / immunology*
Immunoglobulin E / immunology
Intermediate Filament Proteins / metabolism
Langerhans Cells / immunology
Skin / immunology*
Th2 Cells / immunology
Chemical
Reg. No./Substance:
0/Allergens; 0/Cytokines; 0/Intermediate Filament Proteins; 0/filaggrin; 37341-29-0/Immunoglobulin E
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Allergy and the nose.
Next Document:  Breakpoints for posaconazole susceptibility testing: background and discussion about the need of est...