Document Detail

Allergy development and macromolecular absorption in infants with different feeding regimens during the first three days of life. A three-year prospective follow-up.
MedLine Citation:
PMID:  8888916     Owner:  NLM     Status:  MEDLINE    
A group of 129 infants were randomly assigned at birth to one of three feeding regimens: human milk (HM), cow's milk formula (CMF) or a casein hydrolysate formula (CHF) during the first 3 days of life. Blood samples were taken on at 4 days and at 2, 4, 8, 12 and 24 months of age. Macromolecular absorption was analysed by measuring the serum concentration of human alpha-lactalbumin (S-alpha-LA) with a competitive radioimmunoassay (RIA). Total serum IgE was measured by RIA. A family history of allergy correlated to the proportion of infants with allergic symptoms both at 24 and 36 months of age (p = 0.03 and p = 0.04 respectively). In none of the three groups did correlation exist between the duration of breastfeeding and serum alpha-LA, serum IgE, family history of allergy, frequency of allergic symptoms and proportion of infants with infections.
P Juvonen; M Månsson; C Andersson; I Jakobsson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  85     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-07     Completed Date:  1997-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  1047-52     Citation Subset:  IM    
Department of Paediatrics, University of Lund University Hospital, Malmö, Sweden.
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MeSH Terms
Follow-Up Studies
Hypersensitivity* / epidemiology
Immunoglobulin E / blood
Infant Food*
Infant, Newborn
Lactalbumin / blood
Milk, Human*
Prospective Studies
Protein Hydrolysates
Risk Factors
Reg. No./Substance:
0/Caseins; 0/Protein Hydrolysates; 0/trypticase-soy broth; 37341-29-0/Immunoglobulin E; 9013-90-5/Lactalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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