| Allergic transfusion reactions from blood components donated by IgA-deficient donors with and without anti-IgA: a comparative retrospective study. | |
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MedLine Citation:
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PMID: 20345516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: IgA deficiency is common (1/500) and up to 40% of affected individuals will develop anti-IgA. A few studies suggested that passive transfusion of anti-IgA was not associated with an increased risk of allergic reactions. This study was designed to assess the safety of transfusing blood components containing anti-IgA. MATERIALS AND METHODS: IgA-deficient blood donors with and without anti-IgA were identified from Héma-Québec's (HQ) computerized database. IgA deficiency was confirmed by an ELISA method and the presence of anti-IgA by a passive hemagglutination assay. Blood donations from IgA-deficient donors issued to hospitals between March 1999 and December 2004 were retrieved. Medical charts of recipients were reviewed for the occurrence of a suspected transfusion reaction. Presence and nature of transfusion reactions were assessed blindly by an adjudicating committee. RESULTS: A total of 323 IgA-deficient blood products were issued by HQ to 55 hospitals. Of these, 48 agreed to participate [315 blood products (97.5%)]. A total of 272 products were transfused: 174 contained anti-IgA, and 98 did not. Only two minor allergic reactions occurred in each group. Incidence of allergic reactions was 1.15% in the anti-IgA group and 2.04% in the group without anti-IgA (P = 0.91). There was no anaphylactic reaction in either group. CONCLUSIONS: This study indicates that the proportion of allergic reactions does not appear to be greater in recipients of blood components containing anti-IgA compared to recipients of non-anti-IgA-containing components. Allowing donations from IgA-deficient donors with anti-IgA may therefore be contemplated. |
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Authors:
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N Robitaille; G Delage; A Long; L Thibault; P Robillard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-19 |
Journal Detail:
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Title: Vox sanguinis Volume: 99 ISSN: 1423-0410 ISO Abbreviation: Vox Sang. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413606 Medline TA: Vox Sang Country: England |
Other Details:
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Languages: eng Pagination: 136-41 Citation Subset: IM |
Affiliation:
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CHU Sainte-Justine, Montréal, QC, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Anti-Idiotypic
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blood*,
immunology Blood Transfusion / adverse effects* Female Humans Hypersensitivity / blood*, etiology, immunology IgA Deficiency / blood*, immunology Male Middle Aged Platelet Transfusion / adverse effects* Retrospective Studies Tissue Donors |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anti-Idiotypic; 0/anti-IgA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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