Document Detail

Allergic rhinitis and risk of erectile dysfunction--a nationwide population-based study.
MedLine Citation:
PMID:  23346992     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A growing body of evidence has disclosed that allergic rhinitis (AR) is a systemic inflammatory disease. Inflammatory mediators and cells involved in AR have also been reported to be implicated in the process of atherosclerosis, which is relevant to the occurrence of erectile dysfunction (ED). Our objective was to explore the relationship between AR and future ED events.
METHODS: From 1 January 2000 to 31 December 2008, we identified male patients, who were aged 18-55 years and newly diagnosed with AR from the Taiwan National Health Insurance Research Database. A control cohort without AR, which was matched for age, comorbidities and medications, was selected for comparison. The two cohorts were followed up until 31 December 2009 and observed for occurrence of ED by registry of ED diagnosis in the database.
RESULTS: Of the 128,118 sampled male patients (64,059 AR patients vs 64,059 matched controls), 1455 (1.16%) experienced ED during a mean follow-up period of 5.82 years, including 844 (1.32% of the AR patients) from the AR cohort and 611 (0.95%) from the controls. Kaplan-Meier analysis revealed a tendency of AR patients to develop ED (log-rank test, P < 0.001). After adjusting confounder variables by Cox regression, subjects with AR experienced a 1.37-fold (95% CI, 1.24-1.52; P < 0.001) increase in incident ED. The risk of ED was higher in cases with more frequent clinical visits for AR and in cases needing medication more than 4 weeks.
CONCLUSIONS: Patients with AR appeared to be at higher risk of future ED, possibly in a severity-dependent manner.
V Y F Su; C J Liu; M Y Lan; Y M Chen; K C Su; Y C Lee; T J Chen; K T Chou
Publication Detail:
Type:  Journal Article     Date:  2013-01-25
Journal Detail:
Title:  Allergy     Volume:  68     ISSN:  1398-9995     ISO Abbreviation:  Allergy     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-20     Completed Date:  2013-09-06     Revised Date:  2013-11-07    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  440-5     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
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MeSH Terms
Case-Control Studies
Databases, Factual
Erectile Dysfunction / complications*,  epidemiology*
Middle Aged
Population Surveillance
Proportional Hazards Models
Retrospective Studies
Rhinitis, Allergic, Perennial / complications*,  epidemiology*
Young Adult
Comment In:
Allergy. 2013 Sep;68(9):1209-10   [PMID:  24074154 ]
Allergy. 2013 Sep;68(9):1210

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