Document Detail

Allergic reactions to penicillin during in vitro fertilization and intrauterine insemination.
MedLine Citation:
PMID:  1426339     Owner:  NLM     Status:  MEDLINE    
Two cases are reported in which hypersensitivity reactions occurred after intrauterine placement of spermatozoa or embryos. Because the cells were processed and transferred in antibiotic-containing media, these reactions were suspected to be because of penicillin allergy. One patient had no prior penicillin allergy but was found to be penicillin allergic by skin testing. The other had a history of allergy to oral penicillin. In both cases, the allergy symptoms did not occur during subsequent cycles when antibiotics were removed from the transfer media. These reports suggest that in patients known to be penicillin sensitive, penicillin should not be used during transfer of gametes and embryos for assisted reproductive procedures. In addition, the routine use of antibiotics in these procedures should be scientifically evaluated.
Y R Smith; W W Hurd; A C Menge; G M Sanders; R Ansbacher; J F Randolph
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  58     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-11-27     Completed Date:  1992-11-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  847-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor.
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MeSH Terms
Drug Hypersensitivity / etiology*
Fertilization in Vitro*
Insemination, Artificial* / methods
Penicillins / adverse effects*
Reg. No./Substance:

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