Document Detail


Allergic reactions to anisakis simplex parasitizing seafood.
MedLine Citation:
PMID:  9305232     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The ingestion of Anisakidae ssp larvae parasitized fish can cause anisakiasis. Allergic reactions after ingestion of safely cooked but parasitized fish have been reported. METHODS: Twenty-three patients who suffered allergic reactions after seafood ingestion, with negative skin tests were studied. Anisakis simplex sensitization was assessed by skin prick test and/or specific serum Immunoglobulin E (IgE). Total serum IgE and specific IgE against the implicated seafood and Ascaris lumbricoides were also determined. RESULTS: Manifestations of Anisakis simplex allergy were urticaria/angioedema (18/23) patients and anaphylaxis (5/23). Gastric symptoms were also observed (3/23). Sea fish and shellfish were implicated. Raw and cooked seafood ingestion caused reactions. Total serum IgE ranged from 13 to 7200 KU/L. Specific IgE to Anisakis simplex was positive (> 0.35 KU/L) in all patients, and skin tests were positive in 20. Serum-specific IgE and skin tests to the involved seafoods were negative in every patient. Serum-specific IgE to Ascaris lumbricoides was negative in 13 patients. No association between total IgE and the eosinophil count (r < 0.1) was observed, but there was some association between total IgE and specific IgE to Anisakis simplex (r = 0.58). CONCLUSION: Anisakis simplex sensitization is the cause of allergic reactions after seafood ingestion. It is important to pay attention to this new "food allergy" to diagnose correctly the etiology of adverse food reactions.
Authors:
A Moreno-Ancillo; M T Caballero; R Cabañas; J Contreras; J A Martin-Barroso; P Barranco; M C López-Serrano
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  79     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-06     Completed Date:  1997-10-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  246-50     Citation Subset:  IM    
Affiliation:
Allergy Unit, La Paz University General Hospital, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Anaphylaxis / etiology
Angioedema / etiology
Animals
Anisakis / immunology*
Antibodies, Helminth / blood
Antigens, Helminth / adverse effects
Cookery
Eosinophils / cytology
Female
Fishes
Food Hypersensitivity / diagnosis,  etiology*,  parasitology
Humans
Immunoglobulin E / blood
Leukocyte Count
Male
Middle Aged
Seafood / adverse effects*
Skin Tests
Urticaria / etiology
Chemical
Reg. No./Substance:
0/Antibodies, Helminth; 0/Antigens, Helminth; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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