Document Detail

Allergic and irritant contact dermatitis.
MedLine Citation:
PMID:  19447733     Owner:  NLM     Status:  MEDLINE    
Irritant and allergic contact dermatitis are common inflammatory skin diseases induced by repeated skin contact with low molecular weight chemicals, called xenobiotics or haptens. Although both diseases may have similar clinical presentations, they can be differentiated on pathophysiological grounds. Irritant contact dermatitis (ICD) is a non-specific inflammatory dermatitis brought about by activation of the innate immune system by the pro-inflammatory properties of chemicals. Allergic contact dermatitis (ACD) corresponds to a delayed-type hypersensitivity response with a skin inflammation mediated by hapten-specific T cells. Recent progress in the pathophysiology of chemical-induced skin inflammation has shown that ICD and ACD are closely associated and that the best way to prevent ACD is to develop strategies to avoid ICD. The immunological diagnosis of ICD or ACD requires investigation of the presence (ACD) or absence (ICD) of antigen-specific T cells. The detection of T cells can be performed in the skin (collected from ACD lesions or positive patch tests) and/or in the blood, particularly by using the enzyme-linked immunospot assay (ELISPOT). This method, recently developed in ACD to metals, offers a new biological tool enabling the immunobiological diagnosis of ACD.
Audrey Nosbaum; Marc Vocanson; Aurore Rozieres; Anca Hennino; Jean-Fran?ois Nicolas
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of dermatology : EJD     Volume:  19     ISSN:  1167-1122     ISO Abbreviation:  Eur J Dermatol     Publication Date:    2009 Jul-Aug
Date Detail:
Created Date:  2009-07-03     Completed Date:  2009-09-17     Revised Date:  2010-03-08    
Medline Journal Info:
Nlm Unique ID:  9206420     Medline TA:  Eur J Dermatol     Country:  France    
Other Details:
Languages:  eng     Pagination:  325-32     Citation Subset:  IM    
Universit? Lyon 1, UFR Lyon-Sud Charles M?rieux; UF Allergologie et Immunologie Clinique, CH Lyon-Sud; INSERM U 851, IFR 128 Biosciences Lyon-Sud/Gerland.
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MeSH Terms
Allergens / immunology
Dermatitis, Allergic Contact* / diagnosis,  immunology,  physiopathology
Dermatitis, Irritant* / diagnosis,  immunology,  physiopathology
Diagnosis, Differential
Haptens / immunology
Irritants / immunology
Skin Tests
T-Lymphocytes / immunology
Reg. No./Substance:
0/Allergens; 0/Haptens; 0/Irritants
Comment In:
Eur J Dermatol. 2010 Jan-Feb;20(1):125-6   [PMID:  19822484 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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