| Allergic inflammatory reaction is involved in necrosis of human pulmonary dirofilariasis. | |
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MedLine Citation:
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PMID: 17880530 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To determine whether, in view of the massive inflammatory cell infiltration and the rounded rather than wedge-shaped character of pulmonary lesions in dirofilariasis, the inflammatory response against the worm contributes to the coagulative necrosis, in addition to an ischaemic process. METHODS AND RESULTS: The histopathological features of 13 resected dirofilariasis cases with well-defined nodules ranged from 10 to 30 mm were analysed. On routine histology and using immunohistochemistry, the peripheral encapsulating wall showed mild to severe infiltration of eosinophils, lymphocytes and plasma cells and a histiocytic reaction in all cases, often with necrotic eosinophils seen within the necrosis (84.6%) and inflammatory changes in the adjacent lung (38.5%). The CD4+ lymphocyte count (80.8 +/- 33.4) was greater than that of CD8+ lymphocytes (24.5 +/- 16.9) in the central necrosis and vice versa in the wall. In the necrotic regions, disruption of the pulmonary artery (61.5%) and extravasation of the torn worm (23.1%) could be seen. CONCLUSIONS: These findings indicate that an allergic inflammatory reaction, mediated by eosinophils and lymphocytes, is involved in the formation of the dirofilarial necrotizing granuloma rather than infarction caused simply by embolism. |
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Authors:
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J Araya; Y Kawabata; N Tomichi; K Kaneko; K Hayashi; K Iwabuchi; Y Terasaki; T Kawashima; M Watanabe |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Histopathology Volume: 51 ISSN: 0309-0167 ISO Abbreviation: Histopathology Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-20 Completed Date: 2007-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704136 Medline TA: Histopathology Country: England |
Other Details:
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Languages: eng Pagination: 484-90 Citation Subset: IM |
Affiliation:
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Section of Pathology, Saitama Cardiovascular and Respiratory Centre, Saitama, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Animals Dirofilaria / pathogenicity Dirofilariasis / complications, immunology, pathology* Eosinophils / pathology Female Histiocytes / pathology Humans Hypersensitivity / immunology, parasitology*, pathology* Lung / immunology, parasitology*, pathology* Lung Diseases, Parasitic / complications, immunology, pathology* Lymphocytes / pathology Male Middle Aged Necrosis |
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