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Allergic disease in the first year of life is associated with differences in subsequent neurodevelopment and behaviour.
MedLine Citation:
PMID:  22284984     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Recent trials suggest a link between neuropsychological function, atopy and allergic disease particularly in early childhood; however the nature of this association remains unclear. AIMS: To investigate the relationship between early allergic disease and sensitisation at 12months of age and neurodevelopmental outcomes at 18months. STUDY DESIGN: Linear or binary logistic regression analysis was used to determine whether allergic diseases or sensitization at 12months of age was a significant predictor of neurodevelopmental test scores at the 18months. SUBJECTS: Infants with a maternal history of allergic disease (n=324). OUTCOME MEASURES: Allergic outcomes at 12months of age included allergen sensitisation, eczema, IgE-mediated and food allergy, and neurodevelopmental outcomes at 18 included the Bayley Scales of Infant Toddler Development III Edition, the Achenbach Child Behaviour Checklist and the Macarthur Scales of Infant Toddler Development. RESULTS: Children with any diagnosed allergic disease at 12months had evidence of reduced motor scores (p=.016), and this was most apparent for a diagnosis of eczema (p=.007). Non-IgE mediated food allergy was significantly positively associated with problem Internalising Behaviours (p=.010), along with a trend for effects on the Social-Emotional composite score for IgE-Mediated food allergies (p=.052). Allergic sensitisation was not independently associated with any effects on neurodevelopmental outcomes. CONCLUSION: This study provides evidence that an allergic phenotype in infancy is associated with effects on neurodevelopment. Further research is required to investigate the nature of this relationship.
Authors:
Suzanne J Meldrum; Nina D'Vaz; Janet A Dunstan; Trevor A Mori; Kathryn Hird; Karen Simmer; Susan L Prescott
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-25
Journal Detail:
Title:  Early human development     Volume:  -     ISSN:  1872-6232     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ireland Ltd.
Affiliation:
School of Paediatrics and Child Health, University of Western Australia, Perth, Australia; School of Women's and Infants Health, University of Western Australia, Perth, Australia.
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