Document Detail

Allergic bronchopulmonary aspergillosis in patients with and without evidence of bronchiectasis.
MedLine Citation:
PMID:  8466099     Owner:  NLM     Status:  MEDLINE    
Allergic bronchopulmonary aspergillosis (ABPA) may complicate 1% to 2% of all cases of chronic asthma. Twenty-eight patients fulfilling the diagnostic criteria for ABPA but without evidence of proximal bronchiectasis [ABPA-S (seropositive)] were identified over a 12-year period and classified by stage. The majority of patients were in remission but all had chronic asthma. Serum anti-Aspergillus fumigatus (Af) IgG was lower in ABPA-S (n = 28) versus ABPA-CB (central bronchiectasis) (n = 58) at the time of initial presentation (IgG-Af index 3.62 versus 7.80, t = 3.46, P < or = .001). Serum IgG1-Af was significantly lower in ABPA-S as compared with ABPA-CB (t = 2.37, P = .011), as was serum IgG2-Af (t = 1.91, P = .031) and serum IgG4-Af (t = 1.78, P = .041). There were trends toward lower concentrations of total serum IgE, serum anti-Af-IgE, and anti-Af-IgA in ABPA-S. Eleven patients with ABPA-S were evaluated closely for a total of 63 patient-years and only four exacerbations with pulmonary infiltrates were identified. No patient in either group was observed to progress to end-stage or irreversible lung disease when early recognition and treatment were instituted. We conclude that ABPA-S represents the earliest stage or apparently a less aggressive form of ABPA.
P A Greenberger; T P Miller; M Roberts; L L Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of allergy     Volume:  70     ISSN:  0003-4738     ISO Abbreviation:  Ann Allergy     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-06     Completed Date:  1993-05-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372346     Medline TA:  Ann Allergy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  333-8     Citation Subset:  IM    
Department of Medicine, Northwestern University Medical School, Chicago, Illinois.
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MeSH Terms
Antibodies, Fungal / blood
Aspergillosis, Allergic Bronchopulmonary / blood,  complications*,  radiography
Asthma / drug therapy
Bronchiectasis / complications*
Child, Preschool
Forced Expiratory Flow Rates
Immunoglobulin A / blood
Immunoglobulin E / blood
Immunoglobulin G / blood
Middle Aged
Precipitin Tests
Prednisone / therapeutic use
Grant Support
Reg. No./Substance:
0/Antibodies, Fungal; 0/Immunoglobulin A; 0/Immunoglobulin G; 37341-29-0/Immunoglobulin E; 53-03-2/Prednisone

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