Document Detail

Allergic bronchopulmonary aspergillosis as presenting sign of cystic fibrosis in an elderly man.
MedLine Citation:
PMID:  10923608     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although cystic fibrosis is the most common genetic disorder of children, its heterogeneous spectrum of severity lends itself to underdiagnosis in the older adult patient population where the index of suspicion is not high. METHODS: We report a 60-year-old Hispanic man with asthma who presented with progressive dyspnea and wheezing unresponsive to inhaled corticosteroid treatment. Additionally, he had clinical findings and a past history suggestive of cystic fibrosis. Skin testing, radiography and laboratory studies were completed to evaluate for allergic bronchopulmonary aspergillosis (ABPA) and cystic fibrosis. RESULTS: Test results revealed peripheral eosinophilia and hyper IgE. Skin testing to Aspergillus fumigatus (Af) was positive. IgG, IgM, and Af specific antibodies were present. High resolution CT scan showed central bronchiectasis. Sweat tests were positive on two separate occasions and gene analysis showed our patient to have a positive gene mutation at D127ON/D127ON. CONCLUSION: Cystic fibrosis should be suspected in the older adult patient with a compatible clinical presentation.
M E Vilar; N M Najib; I Chowdhry; C W Bassett; B A Silverman; R J Giusti; U W Rosa; A T Schneider
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  85     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-08     Completed Date:  2000-08-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  70-3     Citation Subset:  IM    
Department of Allergy and Immunology, Long Island College Hospital, Brooklyn, New York, USA.
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MeSH Terms
Aspergillosis, Allergic Bronchopulmonary / complications,  diagnosis*
Asthma / complications
Cystic Fibrosis / diagnosis*
Diagnosis, Differential
Family Health
Middle Aged
Respiratory Function Tests
Sputum / microbiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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