Document Detail

Allergic broncho-pulmonary aspergillosis presenting as flitting opacities on chest radiograph.
MedLine Citation:
PMID:  20642954     Owner:  NLM     Status:  MEDLINE    
Allergic broncho-pulmonary aspergillosis (ABPA) is hypersensitivity reaction to Aspergillus fumigatus in the bronchial tree of young asthmatic patients. A 28 years old female patient presented with one year history of fever with generalised body aches and pains and had already received treatment for pulmonary tuberculosis. Her chest radiograph showed flitting opacities in both lung fields with a TLC of 13.2 x 109/L having 25% eosinophils and ESR of 87 mm at first hour. Her serum IgE were markedly raised and CT scan of the chest showed dilated large and medium sized bronchi forming mucocoeles, finger in glove appearance and nodular shadowing in the lung parenchyma. Sputum also showed fungal hyphae by direct microscopy. All the findings were consistent with the diagnosis of ABPA, which responded to oral Itraconazole and Prednisolone. ABPA is a potentially destructive lung disease requiring high index of suspicion for an early diagnosis to prevent irreversible lung damage.
Muhammad Ashraf Sharif; Asad Mahmood; Abdullah Khan; Badar Murtaza; Zunera Asghar
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the College of Physicians and Surgeons--Pakistan : JCPSP     Volume:  20     ISSN:  1022-386X     ISO Abbreviation:  J Coll Physicians Surg Pak     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606447     Medline TA:  J Coll Physicians Surg Pak     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  484-6     Citation Subset:  IM    
Department of Pathology, KRL Hospital, Islamabad, Pakistan.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use
Antifungal Agents / therapeutic use
Aspergillosis, Allergic Bronchopulmonary / drug therapy,  radiography*
Itraconazole / therapeutic use
Prednisolone / therapeutic use
Tomography, X-Ray Computed
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antifungal Agents; 50-24-8/Prednisolone; 84625-61-6/Itraconazole

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