Document Detail

Allergenic components of a novel food, Micronesian nut Nangai (Canarium indicum), shows IgE cross-reactivity in pollen allergic patients.
MedLine Citation:
PMID:  11972478     Owner:  NLM     Status:  MEDLINE    
BACKGROUND:New foods may present a risk for food hypersensitive patients. Several examples exist of allergic reactions caused by cross-reactive plant-derived foods, and new foods should be scrutinised before introducing them to the market. We have evaluated the clinical and serological relevance of cross-reactivity between Nangai and pollen allergens. METHODS: Cross-reactivity was examined with Maxisorp RAST (radioallergosorbent test), RAST inhibition and Western blot, using sera from patients allergic to grass, birch and mugwort pollen. None of the patients reported having seen or eaten Nangai previously. To determine the biological and clinical relevance of the cross-reactivity, histamine release (HR) test, skin prick test (SPT) and food challenge were used. RESULTS: There was prevalence for reactivity against Nangai in the group of pollen allergic patients. This cross-reactivity seems to be related--at least in part--to carbohydrate epitopes. Three out of 12 patients tested with Nangai were positive upon open challenge, but using double blind placebo controlled food challenge (DBPCFC) this could not be confirmed in two patients. The biological effects of Nangai on allergic patients were confirmed using HR and SPT. CONCLUSION: The Nangai specific IgE found among pollen allergic patients addresses the need for control of new or changed foods before introduction to the market.
Eva Sten; P Stahl Skov; S B Andersen; A M Torp; A Olesen; U Bindslev-Jensen; L K Poulsen; C Bindslev-Jensen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy     Volume:  57     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-04-25     Completed Date:  2002-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  398-404     Citation Subset:  IM    
Allergy Unit TTA 7542, National University Hospital, 2200 Copenhagen, Denmark.
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MeSH Terms
Allergens / administration & dosage,  adverse effects*
Antibody Specificity / immunology
Antigens, Differentiation / analysis,  immunology
Binding, Competitive / immunology
Cross Reactions / immunology*
Dose-Response Relationship, Immunologic
Double-Blind Method
Electrophoresis, Polyacrylamide Gel
Galectin 3
Histamine Release / immunology
Hypersensitivity, Immediate / etiology*
Immunodominant Epitopes / immunology
Immunoglobulin E / immunology
Nut Hypersensitivity / etiology*
Nuts / adverse effects*
Plant Extracts / administration & dosage,  adverse effects
Pollen / adverse effects*
Radioallergosorbent Test
Sensitivity and Specificity
Skin Tests
Reg. No./Substance:
0/Allergens; 0/Antigens, Differentiation; 0/Galectin 3; 0/Immunodominant Epitopes; 0/Plant Extracts; 37341-29-0/Immunoglobulin E

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