Document Detail


Allergen-specific pattern recognition receptor pathways.
MedLine Citation:
PMID:  21093238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Allergic diseases continue to plague modernized societies, underscoring the need to identify the molecular basis for the propensity of a small number of environmental proteins to provoke maladaptive, allergic responses. Recent data suggest that the ability of allergenic proteins to drive allergic responses in susceptible hosts is driven by their unique innate immune activating capabilities. Although the identification of allergen-specific pattern recognition receptors is in its infancy, studies to date have shown that allergens drive Th2-biased immune responses via directly engaging C-type lectin receptors (dectin-2, DC-SIGN, and mannose receptor) on dendritic cells and/or mimicking toll-like receptor 4 signaling complex molecules expressed on airway structural cells. Elucidation of the specific innate immune pathways activated by allergens holds great promise in defining new therapeutic targets for the treatment of allergic diseases.
Authors:
Marsha Wills-Karp
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-11-17
Journal Detail:
Title:  Current opinion in immunology     Volume:  22     ISSN:  1879-0372     ISO Abbreviation:  Curr. Opin. Immunol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-06     Completed Date:  2011-03-25     Revised Date:  2013-12-18    
Medline Journal Info:
Nlm Unique ID:  8900118     Medline TA:  Curr Opin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  777-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology*
Humans
Lectins, C-Type / immunology*
Grant Support
ID/Acronym/Agency:
AI070235/AI/NIAID NIH HHS; AI083315/AI/NIAID NIH HHS; ES015903/ES/NIEHS NIH HHS; HL076383/HL/NHLBI NIH HHS; HL67736-09/HL/NHLBI NIH HHS; P01 ES009606/ES/NIEHS NIH HHS; P50 ES015903/ES/NIEHS NIH HHS; R01 AI083315/AI/NIAID NIH HHS; U19 AI070235/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Allergens; 0/Lectins, C-Type
Comments/Corrections

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