Document Detail

Allelic variants of upstream transcription factor 1 associate with carotid artery intima-media thickness: the Cardiovascular Risk in Young Finns study.
MedLine Citation:
PMID:  18577828     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Polymorphisms of the upstream transcription factor 1 (USF1) have been associated with familial combined hyperlipidemia and coronary heart disease. The impact of this gene on subclinical atherosclerosis is unknown. Associations of 3 allelic variants of the USF1 gene and their haplotypes with carotid artery intima - media thickness (IMT), carotid artery compliance (CAC) and brachial artery flow mediated dilatation (FMD) were studied in a population of Finnish healthy young adults. METHODS AND RESULTS: The study population comprised 2,281 individuals participating in the Cardiovascular Risk in Young Finns study. IMT, CAC and FMD values were measured by ultrasound examination. Genotypes were analysed using the 5' nuclease assay. A significant difference in IMT was found for usf1s1 (rs3737787) and usf1s8 (rs2516838) genotypes (p-values 0.046 and 0.021, respectively). Moreover, there was a significant difference between groups in haplotype 1 and haplotype 2 for IMT (p-values 0.011 and 0.028 respectively). In multivariate stepwise linear regression models adjusted by age, sex, body mass index, systolic and diastolic blood pressures, smoking, C-reactive protein, glucose, high- and low-density lipoprotein-cholesterols and triglycerides there were significant associations for the usf1s1 minor genotype AA to predict low IMT (p=0.038) and usf1s8 minor genotype GG to predict high IMT (p=0.003). There was also a significant association for haplotype 2 to predict low IMT in the otherwise similar multivariate model (p=0.006). No associations were found for polymorphisms and CAC, FMD or serum lipids. CONCLUSIONS: The rs2516838 and rs3737787 polymorphisms of USF1 influence the carotid artery IMT, which is a new finding.
Auni Collings; Salla Höyssä; Meng Fan; Mika Kähönen; Nina Hutri-Kähönen; Jukka Marniemi; Markus Juonala; Jorma S A Viikari; Olli T Raitakari; Terho J Lehtimäki
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  72     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-25     Completed Date:  2008-09-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1158-64     Citation Subset:  IM    
Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, PO Box 2000, 33521 Tampere, Finland.
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MeSH Terms
Carotid Arteries / ultrasonography
Carotid Artery Diseases / epidemiology*,  genetics*,  ultrasonography
Child, Preschool
Finland / epidemiology
Gene Frequency
Genetic Predisposition to Disease / epidemiology
Genetic Variation*
Linear Models
Polymorphism, Genetic
Risk Factors
Tunica Intima / ultrasonography
Tunica Media / ultrasonography
Upstream Stimulatory Factors / genetics*
Reg. No./Substance:
0/USF1 protein, human; 0/Upstream Stimulatory Factors

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