Document Detail

Allelic variants of ovine prion protein gene (PRNP) in Oklahoma sheep.
MedLine Citation:
PMID:  14970685     Owner:  NLM     Status:  MEDLINE    
1,144 sheep belonging to 21 breeds and known crosses were sequence analyzed for polymorphisms in the ovine PRNP gene. Genotype and allele frequencies of polymorphisms in PRNP known to confer resistance to scrapie, a fatal neurodegenerative disease of sheep, are reported. Known polymorphisms at codons 136 (A/V), 154 (H/R) and 171 (Q/R/H/K) were identified. The frequency of the 171R allele known to confer resistance to type C scrapie was 53.8% and the frequency of the 136A allele known to influence the resistance to type A scrapie was 96.01%. In addition, we report the identification of five new polymorphisms at codons 143 (H/R), 167 (R/S), 180 (H/Y), 195 (T/S) and 196 (T/S). We also report the identification of a novel allele (S/R) at codon 138.
U DeSilva; X Guo; D M Kupfer; S C Fernando; A T V Pillai; F Z Najar; S So; G Q Fitch; B A Roe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cytogenetic and genome research     Volume:  102     ISSN:  1424-859X     ISO Abbreviation:  Cytogenet. Genome Res.     Publication Date:  2003  
Date Detail:
Created Date:  2004-02-18     Completed Date:  2004-06-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101142708     Medline TA:  Cytogenet Genome Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Department of Animal Science, Oklahoma State University, Stillwater, OK 74078, USA.
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MeSH Terms
Codon / genetics
Gene Frequency / genetics*
Genetic Variation / genetics*
Polymorphism, Genetic / genetics*
PrPC Proteins / genetics*
Scrapie / genetics*
Sheep, Domestic / genetics*
Reg. No./Substance:
0/Codon; 0/PrPC Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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