| Allelic instability as a predictor of survival in Egyptian breast cancer patients. | |
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MedLine Citation:
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PMID: 10493959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This work was designed with the purpose of determining whether the presence of allelic imbalances (AI) such as microsatellite instability (MSI) and loss of heterozygosity (LOH) in chromosomes 2, 11, 13, and 17 in primary breast cancer could be used as prognostic indicators of patient survival. The DNA from breast cancers removed from 29 patients who were followed-up for up to five years was analyzed for MSI and LOH using a panel of 24 markers located at chromosome 2 (TPO, D2S131, D2S144, D2S171, D2S177, D2S119, D2S123, D2S147 and D2S136), chromosome 11 (C-RAS, Int-2, D11S940, D11S912), chromosome 13 (D13S289, D13S260, D13S267, D13S218, D13S263, D13S155, and D13S162), and chromosome 17 (D17S513, TP53, D17S855, and D17S785). The frequency of AI in the markers studied ranged from 30-55%, being highest for D11S912, D2S171, TP53 and D17S855. Univariate analysis showed association between overall survival rate and AI in 9 out of the 24 markers tested. Five of them were located at the area of the mismatch repair gene (MMR)-2 gene, two at 11p, one at 13q and one at 17p. Using multivariate analysis, it was observed that only pathological and clinical stage (defined as stage II or not) and AI at D2S171, D11S912, or D17STP53 generated significant predictive models for survival. |
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Authors:
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A R Zekri; A A Bahnassi; B Bove; Y Huang; I H Russo; A Rogatko; S Shaarawy; O A Shawki; M R Hamza; S Omer; H M Khaled; J Russo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: International journal of oncology Volume: 15 ISSN: 1019-6439 ISO Abbreviation: Int. J. Oncol. Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-11-24 Completed Date: 1999-11-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9306042 Medline TA: Int J Oncol Country: GREECE |
Other Details:
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Languages: eng Pagination: 757-67 Citation Subset: IM |
Affiliation:
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National Cancer Institute and the University of Cairo, Cairo, Egypt. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Breast Neoplasms / diagnosis, genetics*, mortality* Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 17 Chromosomes, Human, Pair 2 Female Follow-Up Studies Humans Loss of Heterozygosity / genetics* Microsatellite Repeats / genetics Middle Aged Neoplasm Staging Polymerase Chain Reaction Polymorphism, Genetic / genetics Prognosis Proportional Hazards Models Survival Rate |
| Grant Support | |
ID/Acronym/Agency:
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R0I CA67238/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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