| Allelic frequencies of host genetic variants influencing susceptibility to HIV-1 infection and disease in South African populations. | |
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MedLine Citation:
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PMID: 10770549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Limited information is available on the prevalence in African populations of host genetic polymorphisms conferring resistance to HIV-1 infection and disease. The objective of this study was to determine the allelic frequencies in South African populations of the chemokine receptor gene variants CCR5delta32, CCR5m303 and CCR2b-641 and the CXCR4 ligand gene variant SDF1-3'A. METHOD: Cross-sectional study to determine the prevalence of these gene variants in South African subjects of African and European descent. RESULTS: The CCR5delta32 genetic variant is rare in individuals of African origin, having an allelic frequency of 0.1% (n = 1247) compared with 9.8% (n = 144) in Caucasians. The CCR5m303 mutation was not detected in Africans (n = 687), whereas an allelic frequency of 0.9% (n = 145) was identified in Caucasians. The frequency of CCR2b-641 allele was 13.1% (n = 180) in Africans, which was significantly higher that the 7.2% (n = 146) detected in Caucasians. Finally the allelic frequency of the SDF1-3'A gene variant was only 1.0% (n = 198) in Africans compared with 19.8% (n = 145) in Caucasians. CONCLUSIONS: These results indicate that genetic polymorphisms conferring resistance to HIV-1 infection are rare in the South African Black population. Except for the CCR2b-641 gene variant, individuals of African origin also had a much lower prevalence of genetic variants associated with prolonged disease progression. |
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Authors:
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C Williamson; S A Loubser; B Brice; G Joubert; T Smit; R Thomas; M Visagie; M Cooper; E van der Ryst |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: AIDS (London, England) Volume: 14 ISSN: 0269-9370 ISO Abbreviation: AIDS Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-06-21 Completed Date: 2000-06-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8710219 Medline TA: AIDS Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 449-51 Citation Subset: IM; X |
Affiliation:
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SAIMR Virology, Department of Medical Microbiology, University of Cape Town, Observatory, South Africa. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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African Continental Ancestry Group
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genetics Alleles* Base Sequence DNA Primers European Continental Ancestry Group / genetics Gene Frequency* Genetic Predisposition to Disease* HIV Infections / epidemiology*, genetics* HIV-1 / isolation & purification Humans Polymorphism, Genetic Receptors, CCR5 / genetics Receptors, CXCR4 / genetics South Africa / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Receptors, CCR5; 0/Receptors, CXCR4 |
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