Document Detail


Allelic frequencies of host genetic variants influencing susceptibility to HIV-1 infection and disease in South African populations.
MedLine Citation:
PMID:  10770549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Limited information is available on the prevalence in African populations of host genetic polymorphisms conferring resistance to HIV-1 infection and disease. The objective of this study was to determine the allelic frequencies in South African populations of the chemokine receptor gene variants CCR5delta32, CCR5m303 and CCR2b-641 and the CXCR4 ligand gene variant SDF1-3'A. METHOD: Cross-sectional study to determine the prevalence of these gene variants in South African subjects of African and European descent. RESULTS: The CCR5delta32 genetic variant is rare in individuals of African origin, having an allelic frequency of 0.1% (n = 1247) compared with 9.8% (n = 144) in Caucasians. The CCR5m303 mutation was not detected in Africans (n = 687), whereas an allelic frequency of 0.9% (n = 145) was identified in Caucasians. The frequency of CCR2b-641 allele was 13.1% (n = 180) in Africans, which was significantly higher that the 7.2% (n = 146) detected in Caucasians. Finally the allelic frequency of the SDF1-3'A gene variant was only 1.0% (n = 198) in Africans compared with 19.8% (n = 145) in Caucasians. CONCLUSIONS: These results indicate that genetic polymorphisms conferring resistance to HIV-1 infection are rare in the South African Black population. Except for the CCR2b-641 gene variant, individuals of African origin also had a much lower prevalence of genetic variants associated with prolonged disease progression.
Authors:
C Williamson; S A Loubser; B Brice; G Joubert; T Smit; R Thomas; M Visagie; M Cooper; E van der Ryst
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS (London, England)     Volume:  14     ISSN:  0269-9370     ISO Abbreviation:  AIDS     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-06-21     Completed Date:  2000-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  449-51     Citation Subset:  IM; X    
Affiliation:
SAIMR Virology, Department of Medical Microbiology, University of Cape Town, Observatory, South Africa.
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group / genetics
Alleles*
Base Sequence
DNA Primers
European Continental Ancestry Group / genetics
Gene Frequency*
Genetic Predisposition to Disease*
HIV Infections / epidemiology*,  genetics*
HIV-1 / isolation & purification
Humans
Polymorphism, Genetic
Receptors, CCR5 / genetics
Receptors, CXCR4 / genetics
South Africa / epidemiology
Chemical
Reg. No./Substance:
0/DNA Primers; 0/Receptors, CCR5; 0/Receptors, CXCR4

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