| Allelic distribution of HLA-B*5 in HLA-B5-positive Israeli patients with Behçet's disease. | |
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MedLine Citation:
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PMID: 11703827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to investigate the sub-typing of the B5 antigen in Israeli (Jewish and Arabic) patients with Behçet's disease (BD) allele-specific genotyping of B51 and B52 alleles was performed in Israeli BD patients and healthy controls. Among the HLA-B51-positive BD patients, B*5101 was found to be the predominant allele, identified in 62% of all BD patients and 78% of Jewish BD patients. HLA-B*5101 was also the predominant allele in HLA-B51-positive healthy controls. HLA-B*5108 and B*5104 alleles were identified in 23% and 15% of B51-positive BD patients, respectively. The HLA-B*5201 allele was identified in all HLA-B52-positive patients and controls. Our study suggests that both HLA-B*5101 and HLA-B*5201 are the dominant alleles of HLA-B5 in Israeli BD patients. |
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Authors:
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M Paul; T Klein; I Krause; Y Molad; R Narinsky; A Weinberger |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Tissue antigens Volume: 58 ISSN: 0001-2815 ISO Abbreviation: Tissue Antigens Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-11-12 Completed Date: 2002-01-25 Revised Date: 2010-11-29 |
Medline Journal Info:
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Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: Denmark |
Other Details:
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Languages: eng Pagination: 185-6 Citation Subset: IM |
Affiliation:
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Department of Medicine B, Rabin Medical Center, Beilinson Campus, Tel Aviv University, Tel Aviv, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Behcet Syndrome / genetics* Gene Frequency* Genes, MHC Class I Genotype HLA-B Antigens / genetics* Humans Israel |
| Chemical | |
Reg. No./Substance:
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0/HLA-B Antigens; 0/HLA-B51; 0/HLA-B52 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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