Document Detail

Alleles of the spontaneously hypertensive rat decrease blood pressure at loci on chromosomes 4 and 13.
MedLine Citation:
PMID:  9299556     Owner:  NLM     Status:  MEDLINE    
In this study the spontaneously hypertensive rat (SHR/Mol) and the spontaneously diabetic BB/OK rat were crossed, and the F1 hybrids were backcrossed onto the BB/OK rat in order to search for cosegregation between blood pressure and loci on chromosomes 4 and 13. Cosegregation of microsatellites on chromosomes 4 (Spr, Npy, D4mit6, Il-6) and 13 (Atp1a2, D13Mit1, D13Uwm1) with blood pressure was evaluated using one-way analysis of variance. On chromosome 4 linkage of the Npy and D4Mit6 markers to systolic blood pressure was observed. A blood pressure QTL was also found on chromosome 13 within the renin locus. Surprisingly, alleles of the SHR strain at loci showing linkage to blood pressure on chromosome 4 and 13 promote lower blood pressure than the same alleles from the BB/OK strain. The transfer of D4Mit6 and renin locus from the SHR rat onto the genetic background of BB/OK rat will probably not lead to a model of diabetic hypertension, but the thorough characterisation of such congenics could contribute to the explanation of genetics and pathophysiology of hypertension in the SHR rat.
P Kovács; B Voigt; I Klöting
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  238     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-16     Completed Date:  1997-10-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  586-9     Citation Subset:  IM    
Copyright Information:
Copyright 1997 Academic Press.
Institute of Pathophysiology, University of Greifswald, Karlsburg, 17495, Germany.
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MeSH Terms
Blood Pressure / genetics*
Chromosome Mapping
Diabetes Mellitus, Type 1 / genetics,  physiopathology*
Hypertension / genetics*
Linkage (Genetics)*
Rats, Inbred BB
Rats, Inbred SHR

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