Document Detail


Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
MedLine Citation:
PMID:  17847008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.
Authors:
Zheng Tan; Glenn Randall; Jihua Fan; Blanca Camoretti-Mercado; Rebecca Brockman-Schneider; Lin Pan; Julian Solway; James E Gern; Robert F Lemanske; Dan Nicolae; Carole Ober
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-08-20
Journal Detail:
Title:  American journal of human genetics     Volume:  81     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-11     Completed Date:  2007-10-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  829-34     Citation Subset:  IM    
Affiliation:
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. tzheng@bsd.uchicago.edu
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MeSH Terms
Descriptor/Qualifier:
3' Untranslated Regions
Alleles
Asthma / genetics*,  immunology*
Base Sequence
Binding Sites / genetics
Female
Genetic Predisposition to Disease
Genotype
HLA Antigens / genetics*
Histocompatibility Antigens Class I / genetics*
Humans
Linkage Disequilibrium
Male
MicroRNAs / chemistry,  genetics*,  metabolism
Polymorphism, Single Nucleotide
Risk Factors
Grant Support
ID/Acronym/Agency:
HD21244/HD/NICHD NIH HHS; HL70831/HL/NHLBI NIH HHS; HL72414/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/3' Untranslated Regions; 0/HLA Antigens; 0/HLA-G antigen; 0/Histocompatibility Antigens Class I; 0/MicroRNAs
Comments/Corrections
Erratum In:
Am J Hum Genet. 2008 Jan;82(1):251

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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