| Allele and genotype frequencies of CYP2C9 in a Korean population. | |
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MedLine Citation:
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PMID: 16187974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To determine the frequencies of the variant alleles and the genotypes of CYP2C9 in a Korean population. METHODS: Three hundred and fifty-eight healthy Korean subjects were studied. CYP2C9 alleles were detected by polymerase chain reaction-restriction fragment length polymorphism assays and direct sequencing assays. RESULTS: The allele frequencies were 0.934 for CYP2C9*1, 0.060 for CYP2C9*3 and 0.006 for CYP2C9*13. The CYP2C9*2,*4,*5 and *11 alleles were not detected. The frequencies of the CYP2C9*1/*1, *1/*3 and *1/*13 genotypes were 0.869, 0.120 and 0.011, respectively. CONCLUSION: The frequency of the CYP2C9*3 allele in the Korean population studied was significantly higher than reported elsewhere, and a novel allele, CYP2C9*13, was found at a frequency of 0.006 (95% confidence interval 0, 0.012). Only three genotypes of CYP2C9, CYP2C9*1/*1,*1/*3 and *1/*13 were observed in this Korean population. |
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Authors:
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Jung-Woo Bae; Hyun-Kyung Kim; Ji-Hong Kim; Sang-In Yang; Mi-Jeong Kim; Choon-Gon Jang; Young-Seo Park; Seok-Yong Lee |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 60 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-28 Completed Date: 2006-08-21 Revised Date: 2013-06-07 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 418-22 Citation Subset: IM |
Affiliation:
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Laboratory of Pharmacology, College of Pharmacy, Sungkyunkwan University, Suwon, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aryl Hydrocarbon Hydroxylases / genetics* Asian Continental Ancestry Group / genetics Female Gene Frequency* Humans Korea / ethnology Male Polymorphism, Genetic / genetics* |
| Chemical | |
Reg. No./Substance:
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EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/CYP2C9 protein, human |
| Comments/Corrections | |
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