Document Detail


Allele frequencies for candidate genes in atherosclerosis and diabetes among Trinidadian neonates.
MedLine Citation:
PMID:  11512679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Trinidadians of South Asian origin have a high prevalence of cardiovascular disease and diabetes compared to Trinidadians of African origin. The degree to which these differences are related to genetic and/or environmental factors is unclear. To determine whether there might be a genetic basis for this difference in prevalence of deleterious phenotypes we examined allele frequencies for candidate genes in atherosclerosis and diabetes. We genotyped 81 consecutive neonates of African origin and 103 consecutive neonates of South Asian origin. We evaluated common polymorphisms in 11 candidate genes for atherosclerosis and diabetes. We found differences between the two subpopulations in the allele frequencies of several candidate genes, including APOE, LIPC, APOC3, PON1, PON2, and PPP1R3. However, the differences in the allele frequencies were not all consistent with the pattern of CHD expression between these two ethnic groups in adulthood. Thus, differences in genetic architecture alone may not explain the wide disparities in disease prevalence between these two subpopulations. It is very likely that environmental factors, or unmeasured genetic factors, influence the genetic susceptibility to disease in these subpopulations.
Authors:
R A Hegele; M R Ban; C V Carrington; D D Ramdath
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human biology     Volume:  73     ISSN:  0018-7143     ISO Abbreviation:  Hum. Biol.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-21     Completed Date:  2001-09-27     Revised Date:  2011-04-18    
Medline Journal Info:
Nlm Unique ID:  0116717     Medline TA:  Hum Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  525-31     Citation Subset:  IM    
Affiliation:
John P. Robarts Research Institute, University of Western Ontario, London, Canada.
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MeSH Terms
Descriptor/Qualifier:
Africa / ethnology
Arteriosclerosis / ethnology*,  genetics*
Asia, Southeastern / ethnology
Diabetes Mellitus, Type 2 / ethnology*,  genetics*
Fetal Blood
Gene Frequency / genetics*
Genetic Markers / genetics
Genetic Predisposition to Disease / genetics
Humans
Infant, Newborn
Phenotype
Polymorphism, Genetic / genetics*
Prevalence
Risk Factors
Trinidad and Tobago / epidemiology
Chemical
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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