| Allele distribution at the FMR1 locus in the general Chinese population. | |
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MedLine Citation:
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PMID: 10422806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fragile X syndrome is an important disease of hereditary mental retardation. Its prevalence in the Chinese population is not clear. We amplified FMR1 CGG repeats from male newborns' blood spots. Approximately 45% of the males had 28 CGG repeats and another 19% had 29 repeats. Besides this major peak, there was a second peak at 34 and 35 repeats. From the 1000 males studied, 3 were found to have repeat numbers in the high borderline range (each with 50, 52 and 53 repeats). This result provides a low but significant risk of fragile X syndrome in the Chinese population. |
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Authors:
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S C Chiang; Y M Lee; T R Wang; W L Hwu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical genetics Volume: 55 ISSN: 0009-9163 ISO Abbreviation: Clin. Genet. Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-08-24 Completed Date: 1999-08-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0253664 Medline TA: Clin Genet Country: DENMARK |
Other Details:
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Languages: eng Pagination: 352-5 Citation Subset: IM |
Affiliation:
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Department of Medical Genetics and Pediatrics, College of Medicine, National Taiwan University, Taipei, Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles* China / ethnology Fragile X Mental Retardation Protein Fragile X Syndrome / ethnology, genetics* Gene Frequency* Humans Infant, Newborn Male Nerve Tissue Proteins / genetics* Polymerase Chain Reaction RNA-Binding Proteins* Taiwan Trinucleotide Repeats |
| Chemical | |
Reg. No./Substance:
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0/FMR1 protein, human; 0/Nerve Tissue Proteins; 0/RNA-Binding Proteins; 139135-51-6/Fragile X Mental Retardation Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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