Document Detail


All wrapped up.
MedLine Citation:
PMID:  9546210     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
How is it possible that nine small repeated 'zinc finger' units (each spanning just 3 or 4 base pairs) can protect the whole 50 base pair binding site of TFIIIA and why should such a periodic protein structure give rise to such an asymmetric footprint on DNA? The crystal structure of the first six fingers of TFIIIA bound to 31 base pairs of DNA explains everything: not all zinc fingers act alike.
Authors:
Y Choo; J W Schwabe
Publication Detail:
Type:  News    
Journal Detail:
Title:  Nature structural biology     Volume:  5     ISSN:  1072-8368     ISO Abbreviation:  Nat. Struct. Biol.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-04-24     Completed Date:  1998-04-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9421566     Medline TA:  Nat Struct Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  253-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Composition
Base Sequence
Binding Sites
DNA / chemistry*,  metabolism*
Models, Molecular
Nucleic Acid Conformation
Protein Conformation
RNA, Ribosomal, 5S / genetics
Transcription Factor TFIIA
Transcription Factors / chemistry*,  metabolism*
Xenopus
Zinc Fingers*
Chemical
Reg. No./Substance:
0/RNA, Ribosomal, 5S; 0/Transcription Factor TFIIA; 0/Transcription Factors; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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