Document Detail


All-trans retinoyl beta-glucose: chemical synthesis, growth-promoting activity, and metabolism in the rat.
MedLine Citation:
PMID:  1794956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
All-trans retinoyl beta-glucose was chemically synthesized in good yield by reaction of retinoyl fluoride with glucose. Retinoyl glucose, which is soluble in water, shows growth-promoting activity similar to retinyl acetate in vitamin A-deficient rats. In metabolic studies, retinoyl glucose was found to be hydrolyzed to retinoic acid, but at a slower rate. The possible therapeutic uses of retinoyl glucose are discussed.
Authors:
A B Barua; J A Olson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  61     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  1991  
Date Detail:
Created Date:  1992-04-08     Completed Date:  1992-04-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  258-63     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Biophysics, Iowa State University, Ames 50011.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects*
Chromatography, High Pressure Liquid
Glucose / analogs & derivatives*,  chemical synthesis,  metabolism,  therapeutic use
Male
Rats
Rats, Inbred Strains
Retinoids / isolation & purification
Tretinoin / analogs & derivatives*,  chemical synthesis,  metabolism,  therapeutic use
Vitamin A Deficiency / drug therapy,  metabolism,  physiopathology
Grant Support
ID/Acronym/Agency:
DK 39733/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Retinoids; 0/retinoylglucose; 302-79-4/Tretinoin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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