Document Detail

All-trans retinoic acid for the treatment of acute promyelocytic leukemia in pregnancy.
MedLine Citation:
PMID:  9166337     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute promyelocytic leukemia, a subset of acute myelogenous leukemia, is commonly associated with disseminated intravascular coagulation (DIC). All-trans retinoic acid is effective in the treatment of acute promyelocytic leukemia and may prevent an exacerbation of DIC. There is limited information, however, regarding the use of this agent in pregnancy. CASE: A 29-year-old woman with acute promyelocytic leukemia and DIC at 24 weeks' gestation was treated successfully with all-trans retinoic acid during the pregnancy, delivering a viable, normal infant at 33 weeks. CONCLUSION: This case illustrates the successful use of all-trans retinoic acid in pregnancy for the treatment of acute promyelocytic leukemia. With the combined, intensive efforts of the perinatal, neonatal, and hematology-oncology services, a favorable outcome was achieved.
M H Incerpi; D A Miller; R Posen; J D Byrne
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  89     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-24     Completed Date:  1997-06-24     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  826-8     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, LAC+USC Women's and Children's Hospital, USA.
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MeSH Terms
Antineoplastic Agents / therapeutic use*
Bone Marrow Examination
Disseminated Intravascular Coagulation / etiology
Labor, Induced
Leukemia, Promyelocytic, Acute / complications,  drug therapy*
Pregnancy Complications, Hematologic / drug therapy*
Pregnancy Outcome
Pregnancy Trimester, Second
Remission Induction
Tretinoin / therapeutic use*
Reg. No./Substance:
0/Antineoplastic Agents; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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