| All-trans retinoic acid for the treatment of acute promyelocytic leukemia in pregnancy. | |
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MedLine Citation:
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PMID: 9166337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Acute promyelocytic leukemia, a subset of acute myelogenous leukemia, is commonly associated with disseminated intravascular coagulation (DIC). All-trans retinoic acid is effective in the treatment of acute promyelocytic leukemia and may prevent an exacerbation of DIC. There is limited information, however, regarding the use of this agent in pregnancy. CASE: A 29-year-old woman with acute promyelocytic leukemia and DIC at 24 weeks' gestation was treated successfully with all-trans retinoic acid during the pregnancy, delivering a viable, normal infant at 33 weeks. CONCLUSION: This case illustrates the successful use of all-trans retinoic acid in pregnancy for the treatment of acute promyelocytic leukemia. With the combined, intensive efforts of the perinatal, neonatal, and hematology-oncology services, a favorable outcome was achieved. |
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Authors:
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M H Incerpi; D A Miller; R Posen; J D Byrne |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 89 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-06-24 Completed Date: 1997-06-24 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 826-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, LAC+USC Women's and Children's Hospital, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Agents / therapeutic use* Bone Marrow Examination Disseminated Intravascular Coagulation / etiology Female Humans Labor, Induced Leukemia, Promyelocytic, Acute / complications, drug therapy* Pregnancy Pregnancy Complications, Hematologic / drug therapy* Pregnancy Outcome Pregnancy Trimester, Second Remission Induction Tretinoin / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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