| All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease. | |
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MedLine Citation:
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PMID: 19903021 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Retinoic acid, an essential factor derived from vitamin A, has been shown to have a variety of functions including roles as an antioxidant and in cellular differentiation. Since oxidative stress and dedifferentiation of neurons appear to be common pathological elements of a number of neurodegenerative disorders, we speculated that retinoic acid may offer therapeutic promise. In this vein, recent compelling evidence indicates a role of retinoic acid in cognitive activities and anti-amyloidogenic properties. Here, we review the actions of retinoic acid that indicate that it may have therapeutic properties ideally served for the treatment of neurodegenerative diseases such as Alzheimer's disease. |
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Authors:
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Hyun-Pil Lee; Gemma Casadesus; Xiongwei Zhu; Hyoung-gon Lee; George Perry; Mark A Smith; Katarzyna Gustaw-Rothenberg; Alan Lerner |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Expert review of neurotherapeutics Volume: 9 ISSN: 1744-8360 ISO Abbreviation: Expert Rev Neurother Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-11 Completed Date: 2010-01-22 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 101129944 Medline TA: Expert Rev Neurother Country: England |
Other Details:
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Languages: eng Pagination: 1615-21 Citation Subset: IM |
Affiliation:
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Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. hxl204@case.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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drug therapy* Animals Brain / drug effects* Humans Neuroprotective Agents / pharmacology* Tretinoin / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG026151/AG/NIA NIH HHS; R01 AG026151-03/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neuroprotective Agents; 302-79-4/Tretinoin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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