| All things must pass: contrasts and commonalities in eukaryotic and bacterial mRNA decay. | |
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MedLine Citation:
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PMID: 20520623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite its universal importance for controlling gene expression, mRNA degradation was initially thought to occur by disparate mechanisms in eukaryotes and bacteria. This conclusion was based on differences in the structures used by these organisms to protect mRNA termini and in the RNases and modifying enzymes originally implicated in mRNA decay. Subsequent discoveries have identified several striking parallels between the cellular factors and molecular events that govern mRNA degradation in these two kingdoms of life. Nevertheless, some key distinctions remain, the most fundamental of which may be related to the different mechanisms by which eukaryotes and bacteria control translation initiation. |
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Authors:
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Joel G Belasco |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-06-03 |
Journal Detail:
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Title: Nature reviews. Molecular cell biology Volume: 11 ISSN: 1471-0080 ISO Abbreviation: Nat. Rev. Mol. Cell Biol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-07-07 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 100962782 Medline TA: Nat Rev Mol Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 467-78 Citation Subset: IM |
Affiliation:
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Kimmel Center for Biology and Medicine at the Skirball Institute and Department of Microbiology, New York University School of Medicine, New York, 10016, USA. joel.belasco@med.nyu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Eukaryotic Cells / metabolism* Humans Models, Biological RNA Stability / genetics* RNA, Bacterial / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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GM35769/GM/NIGMS NIH HHS; GM79477/GM/NIGMS NIH HHS; R01 GM035769-24/GM/NIGMS NIH HHS; R01 GM035769-25/GM/NIGMS NIH HHS; R01 GM079477-03/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/RNA, Bacterial |
| Comments/Corrections | |
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