Document Detail


All things must pass: contrasts and commonalities in eukaryotic and bacterial mRNA decay.
MedLine Citation:
PMID:  20520623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite its universal importance for controlling gene expression, mRNA degradation was initially thought to occur by disparate mechanisms in eukaryotes and bacteria. This conclusion was based on differences in the structures used by these organisms to protect mRNA termini and in the RNases and modifying enzymes originally implicated in mRNA decay. Subsequent discoveries have identified several striking parallels between the cellular factors and molecular events that govern mRNA degradation in these two kingdoms of life. Nevertheless, some key distinctions remain, the most fundamental of which may be related to the different mechanisms by which eukaryotes and bacteria control translation initiation.
Authors:
Joel G Belasco
Related Documents :
12198173 - Functional cloning of brf1, a regulator of are-dependent mrna turnover.
23624403 - Bi-directional interconversion of brite and white adipocytes.
19490803 - Expression of glutaredoxin-1 in nasal polyps and airway epithelial cells.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-06-03
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  11     ISSN:  1471-0080     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-07-07     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  467-78     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Eukaryotic Cells / metabolism*
Humans
Models, Biological
RNA Stability / genetics*
RNA, Bacterial / genetics*
Grant Support
ID/Acronym/Agency:
GM35769/GM/NIGMS NIH HHS; GM79477/GM/NIGMS NIH HHS; R01 GM035769/GM/NIGMS NIH HHS; R01 GM035769-24/GM/NIGMS NIH HHS; R01 GM079477/GM/NIGMS NIH HHS; R01 GM079477-03/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Bacterial
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A membranous spindle matrix orchestrates cell division.
Next Document:  The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and...