| All-dry synthesis and coating of methacrylic acid copolymers for controlled release. | |
| | |
MedLine Citation:
|
PMID: 17429803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Initiated chemical vapor deposition (iCVD) is presented as an all-dry synthesis and coating method for applying methacrylic acid copolymers as pH-responsive controlled release layers. iCVD combines the strengths of liquid-phase chemical synthesis with a precision solvent-free chemical vapor deposition environment. Copolymers of methacrylic acid and ethyl acrylate were confirmed by a systematic shift in the carbonyl bond stretching mode with a shift in the comonomer ratio within the copolymer and by the ability to apply the Fineman-Ross copolymerization equation to describe copolymerization kinetics. Copolymers of methacrylic acid and ethylene dimethacrylate showed pH-dependent swelling behavior that was applied to the enteric release of fluorescein and ibuprofen. |
| | |
Authors:
|
Kenneth K S Lau; Karen K Gleason |
Related Documents
:
|
12502373 - Synthesis and in vivo antitumor activity of poly(l-glutamic acid) conjugates of 20s-cam... 18563053 - Acidic polyanion poly(acrylic acid) prevents calcium oxalate crystal deposition. 1368713 - The amino acid sequence of reeves' pheasant (syrmaticus reevesii) lysozyme. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Macromolecular bioscience Volume: 7 ISSN: 1616-5187 ISO Abbreviation: Macromol Biosci Publication Date: 2007 Apr |
Date Detail:
|
Created Date: 2007-04-17 Completed Date: 2007-10-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: Germany |
Other Details:
|
Languages: eng Pagination: 429-34 Citation Subset: IM |
Affiliation:
|
Department of Chemical and Biological Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, USA. klau@drexel.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acrylates
/
chemistry* Analgesics, Non-Narcotic / chemistry Delayed-Action Preparations Drug Carriers / chemical synthesis*, chemistry Fluorescein / chemistry Hydrogen-Ion Concentration Ibuprofen / chemistry Methacrylates / chemistry* Polymethacrylic Acids / chemical synthesis*, chemistry Volatilization |
| Chemical | |
Reg. No./Substance:
|
0/Acrylates; 0/Analgesics, Non-Narcotic; 0/Delayed-Action Preparations; 0/Drug Carriers; 0/Methacrylates; 0/Polymethacrylic Acids; 140-88-5/ethyl acrylate; 15687-27-1/Ibuprofen; 2321-07-5/Fluorescein; 79-41-4/methacrylic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of alpha-tocopherol, propolis and piperine on therapeutic potential of tiferron against be...
Next Document: Ferrocene branched chitosan for the construction of a reagentless amperometric hydrogen peroxide bio...