| All children who experience epileptic falls do not necessarily have Lennox-Gastaut syndrome... but many do. | |
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MedLine Citation:
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PMID: 21669558 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lennox-Gastaut syndrome (LGS) is a severe, chronic, epileptic encephalopathy, primarily with childhood onset, which is characterised by a triad of features: multiple seizure types, including tonic seizures that may appear late in the course of the disorder; abnormal EEG features with slow spike-wave discharges; and cognitive impairment. Recognition of LGS is problematic, since the seizure types and EEG features that characterise it are not pathognomonic and often change over time. Furthermore, although seizures associated with LGS may occur de novo, the appearance of core LGS seizures may be preceded by prolonged periods of other seizure types, including myoclonic seizures, partial seizures, or infantile spasms. This has led some authors to postulate that a continuum between LGS and other types of childhood epilepsy may exist. Accurate diagnosis requires careful assessment of both clinical and EEG features, in order to distinguish LGS from other childhood epilepsy syndromes, such as atypical benign partial epilepsy of childhood, Dravet syndrome or epilepsies with predominantly myoclonic-astatic seizures. Since there is no biological marker that can be used to confirm diagnosis of LGS and because of the multiple aetiologies that could lead to its development, early referral to a specialist team may prove to be crucial for facilitating both diagnosis and management. Such an approach ensures that patients receive the appropriate treatment at the correct time, providing the best opportunity for the clinical course and overall prognosis to be improved. Effective management of LGS requires regular reappraisal of the evolving symptoms and features, and adjustment of the treatment accordingly. |
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Authors:
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Alexis Arzimanoglou; Trevor Resnick |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Epileptic disorders : international epilepsy journal with videotape Volume: 13 ISSN: 1294-9361 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-6-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100891853 Medline TA: Epileptic Disord Country: - |
Other Details:
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Languages: ENG Pagination: 3-13 Citation Subset: - |
Affiliation:
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Institute for Children and Adolescents with Epilepsy - IDEE, University Hospital of Lyon (HCL)Institute for Children and Adolescents with Epilepsy - IDEE, University Hospital of Lyon (HCL)Institute for Children and Adolescents with Epilepsy - IDEE, University Hospital of Lyon (HCL)Institute for Children and Adolescents with Epilepsy - IDEE, University Hospital of Lyon (HCL). |
Vernacular Title:
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All children who experience epileptic falls do not necessarily have Lennox-Gastaut syndrome... but many do. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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