| Alkyltransferase-like proteins: molecular switches between DNA repair pathways. | |
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MedLine Citation:
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PMID: 20502938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alkyltransferase-like proteins (ATLs) play a role in the protection of cells from the biological effects of DNA alkylation damage. Although ATLs share functional motifs with the DNA repair protein and cancer chemotherapy target O⁶-alkylguanine-DNA alkyltransferase, they lack the reactive cysteine residue required for alkyltransferase activity, so its mechanism for cell protection was previously unknown. Here we review recent advances in unraveling the enigmatic cellular protection provided by ATLs against the deleterious effects of DNA alkylation damage. We discuss exciting new evidence that ATLs aid in the repair of DNA O⁶-alkylguanine lesions through a novel repair cross-talk between DNA-alkylation base damage responses and the DNA nucleotide excision repair pathway. |
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Authors:
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Julie L Tubbs; John A Tainer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-05-26 |
Journal Detail:
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Title: Cellular and molecular life sciences : CMLS Volume: 67 ISSN: 1420-9071 ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-18 Completed Date: 2010-11-16 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: Switzerland |
Other Details:
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Languages: eng Pagination: 3749-62 Citation Subset: IM |
Affiliation:
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Department of Molecular Biology, Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals DNA / chemistry, metabolism* DNA Repair* Humans Models, Molecular Molecular Sequence Data O(6)-Methylguanine-DNA Methyltransferase / chemistry, metabolism* Sequence Alignment Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA097209-08/CA/NCI NIH HHS; R01 CA097209-08S1/CA/NCI NIH HHS; R01 CA097209-09/CA/NCI NIH HHS; R01CA097209/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA; EC 2.1.1.63/O(6)-Methylguanine-DNA Methyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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