Document Detail

Alkylresorcinols as biomarkers of whole-grain wheat and rye intake: plasma concentration and intake estimated from dietary records.
MedLine Citation:
PMID:  18400704     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Alkylresorcinols (ARs), phenolic lipids exclusively present in the outer parts of wheat and rye grains, have been proposed as specific dietary biomarkers of whole-grain wheat and rye intake. OBJECTIVE: The objective was to validate plasma ARs as a biomarker of whole-grain wheat and rye intakes by studying the correlation between their plasma concentration and intake calculated from food records. DESIGN: In a randomized crossover study, 22 women and 8 men were given a defined amount of either whole-grain or refined-cereal-grain products to be included in their habitual diets for two 6-wk periods. Blood samples were collected and food intakes were recorded before and after each intervention period. RESULTS: Plasma AR concentrations were significantly higher after the whole-grain diet period than after the refined-grain period (P < 0.0001) and were well correlated with average daily AR intake estimated by self-reported weighed food records (Spearman's r = 0.58, P < 0.001). CONCLUSION: Plasma AR concentrations are correlated with intake assessed by food records, which suggests that ARs are selective nutritional biomarkers for the intake of whole-grain wheat and rye.
Rikard Landberg; Afaf Kamal-Eldin; Agneta Andersson; Bengt Vessby; Per Aman
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  87     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-10     Completed Date:  2008-04-28     Revised Date:  2009-05-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  832-8     Citation Subset:  AIM; IM    
Department of Food Science, Swedish University of Agriculture Science, Uppsala, Sweden.
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MeSH Terms
Biological Markers / blood
Cross-Over Studies
Diet Records
Dietary Fiber / administration & dosage
Food Habits
Middle Aged
Patient Compliance
Resorcinols / administration & dosage*,  blood*
Secale cereale* / chemistry
Statistics, Nonparametric
Triticum* / chemistry
Reg. No./Substance:
0/Biological Markers; 0/Resorcinols
Comment In:
Am J Clin Nutr. 2008 Apr;87(4):797-8   [PMID:  18400698 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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