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Alkyl esters of gallic acid as anticancer agents: A review.
MedLine Citation:
PMID:  23291333     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The current review presents the antitumoral properties of gallic acid and its ester derivatives. Numerous studies have indicated that the alkyl esters are more effective against tumor cell lines than gallic acid, and that this activity is related to their hydrophobic moiety. All related studies have shown that the antitumor activity is interconnected to the induction of apoptosis by different mechanisms and it depends on the cell type. The results presented in this review may help to emphasize that these compounds could be promising as a new alternative for the treatment of cancer, either alone or in combination with other antitumor drugs to potentiate their effects.
Authors:
Claudriana Locatelli; Fabíola Branco Filippin-Monteiro; Tânia Beatriz Creczynski-Pasa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-30
Journal Detail:
Title:  European journal of medicinal chemistry     Volume:  60C     ISSN:  1768-3254     ISO Abbreviation:  Eur J Med Chem     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0420510     Medline TA:  Eur J Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  233-239     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Affiliation:
Curso de Farmácia, Universidade do Oeste de Santa Catarina, Videira, SC 89560-000, Brazil; Universidade do Alto Vale do Rio do Peixe, Caçador, SC 89500-000, Brazil.
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