| Alkaptonuria presenting as lumbar disc prolapse: case report and review of literature. | |
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MedLine Citation:
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PMID: 9670391 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alkaptonuria is a rare genetic disorder caused by deficiency of the enzyme homogentisic acid oxidase, resulting in accumulation of homogentisic acid in various body tissue; it produces a multisystemic disorder with a characteristic bluish-black discolouration of the skin and cartilage, termed ochranosis. Ochranosis primarily involves the large joints of the body including the spine. Spinal involvement produces loss of flexibility and ankylosis of the thoracic and lumbar segments. The clinical presentation with spondylosis and canal stenosis is common after the third and fourth decades, but intervertebral disc prolapse is unusual in ochranosis. |
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Authors:
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D R Reddy; V S Prasad |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Spinal cord Volume: 36 ISSN: 1362-4393 ISO Abbreviation: Spinal Cord Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-10-13 Completed Date: 1998-10-13 Revised Date: 2011-06-06 |
Medline Journal Info:
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Nlm Unique ID: 9609749 Medline TA: Spinal Cord Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 523-4 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Apollo Hospitals, Hyderabad, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alkaptonuria / diagnosis* Diagnosis, Differential Humans Intervertebral Disk Displacement / diagnosis*, surgery Laminectomy Lumbar Vertebrae* / surgery Male Pain Measurement |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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