Document Detail

Alkaptonuria presenting as lumbar disc prolapse: case report and review of literature.
MedLine Citation:
PMID:  9670391     Owner:  NLM     Status:  MEDLINE    
Alkaptonuria is a rare genetic disorder caused by deficiency of the enzyme homogentisic acid oxidase, resulting in accumulation of homogentisic acid in various body tissue; it produces a multisystemic disorder with a characteristic bluish-black discolouration of the skin and cartilage, termed ochranosis. Ochranosis primarily involves the large joints of the body including the spine. Spinal involvement produces loss of flexibility and ankylosis of the thoracic and lumbar segments. The clinical presentation with spondylosis and canal stenosis is common after the third and fourth decades, but intervertebral disc prolapse is unusual in ochranosis.
D R Reddy; V S Prasad
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Spinal cord     Volume:  36     ISSN:  1362-4393     ISO Abbreviation:  Spinal Cord     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-10-13     Completed Date:  1998-10-13     Revised Date:  2011-06-06    
Medline Journal Info:
Nlm Unique ID:  9609749     Medline TA:  Spinal Cord     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  523-4     Citation Subset:  IM    
Department of Neurosurgery, Apollo Hospitals, Hyderabad, India.
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MeSH Terms
Alkaptonuria / diagnosis*
Diagnosis, Differential
Intervertebral Disk Displacement / diagnosis*,  surgery
Lumbar Vertebrae* / surgery
Pain Measurement

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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