Document Detail


Alkaloids from the roots of Stemona aphylla.
MedLine Citation:
PMID:  19374387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three known compounds, stemofoline (1), (2'S)-hydroxystemofoline (2), and (11Z)-1',2'-didehydrostemofoline (3), along with two new alkaloids, stemaphylline (4) and stemaphylline-N-oxide (5), have been isolated from a root extract of Stemona aphylla. The structures of these alkaloids were determined on the basis of their spectroscopic data. The analysis of the crude dichloromethane extract by GC-MS in the EIMS mode showed the presence of alkaloids 1-4, the alkaloid 11, and stilbostemin R (12). The crude dichloromethane extract and 4 were tested for their comparative biological activities. The results of their acetylcholinesterase (AChE) inhibitory activities showed that the crude extract had higher activity than that of 4. The insecticidal properties of the crude extract and 4, using a topical application, showed that 4 had an activity similar to the positive control, methomyl, whereas the crude extract had much lower activity. Their antimicrobial activity against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas auruginosa ATCC 27853, and Candida albicans ATCC 90028 was weak (MIC 62.5-125 microg/mL, MBC 125-250 microg/mL, MFC 125 microg/mL) but much higher than that of the crude extract.
Authors:
Pitchaya Mungkornasawakul; Sukanda Chaiyong; Thanapat Sastraruji; Araya Jatisatienr; Chaiwat Jatisatienr; Stephen G Pyne; Alison T Ung; John Korth; Wilford Lie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of natural products     Volume:  72     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2009 May 
Date Detail:
Created Date:  2010-06-21     Completed Date:  2010-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  848-51     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of Wollongong, Wollongong, New South Wales 2522, Australia. pitchaya@uow.edu.au
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MeSH Terms
Descriptor/Qualifier:
Alkaloids / chemistry,  isolation & purification*,  pharmacology
Animals
Candida albicans / drug effects
Cholinesterase Inhibitors / chemistry,  isolation & purification*,  pharmacology
Escherichia coli / drug effects
Gas Chromatography-Mass Spectrometry
Heterocyclic Compounds with 4 or More Rings / chemistry,  isolation & purification
Insecticides / isolation & purification,  pharmacology
Microbial Sensitivity Tests
Molecular Structure
Moths / drug effects
Nuclear Magnetic Resonance, Biomolecular
Oxidation-Reduction
Plant Roots / chemistry
Plants, Medicinal / chemistry*
Pseudomonas aeruginosa / drug effects
Staphylococcus aureus / drug effects
Stemonaceae / chemistry*
Stereoisomerism
Thailand
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Cholinesterase Inhibitors; 0/Heterocyclic Compounds with 4 or More Rings; 0/Insecticides; 0/stemaphylline; 0/stemaphylline-N-oxide; 29881-57-0/stemofoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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