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Alkaloids from Piper: A Review of itsPhytochemistry and Pharmacology.
MedLine Citation:
PMID:  23279257     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objetive:Piper has been used for long timelike condiment and food, but also in traditional medicine around of the world. This work resumes the available and up to date work done on members of the Piperaceae family and their uses for therapeutic purposes. Methods:InformationonPiper genus was gathered via internet using scientific databases such as Scirus, Google Scholar, CAB-abstracts, MedlinePlus, Pubmed, SciFinder, Scopus and Web of Science. Results:The large-leafed perennial plant Piper is used for its spicy aromatic scent and flavor. Ithas an important presence in the cuisine of different cultures. Another quality of these plants is their known medicinal properties. It has been used as emollient, anti-rheumatic, diuretic, stimulant, abortifacient, anti-inflammatory, antibacterial, antifungal and antidermatophytic. A survey of the literature shows that the genus Piper is mainly known for its alkaloids with cytotoxic, chemopreventive, anti-metastatic and antitumor properties in several types of cancer. Studies of its alkaloids highlight the existence of various potential leads to develop new anti-cancer agents. Modern pharmacology studies have demonstrated that its crude extracts and active compounds possess wide pharmacological activities, especially asantioxidant, anti-depressive, hepatoprotective, antimicrobial, anti-obesity, neuropharmacological, to treat cognitive disorders, anti-hyperlipidemic,anti-feedant, cardioactive, immuno-enhancing, and anti-inflamatory. All this evidence supporting its traditional uses. Aim of the review: This review summarizes the up-to-date and comprehensive information concerning the botany, traditional use, phytochemistry and pharmacology of Piper together with its toxicology, and discusses the possible trend and scope for further research on Piper in the future.
Authors:
Rosa Martha Perez Gutierrez; Adriana Maria Neira Gonzalez; Carlos Hoyo-Vadillo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-31
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  -     ISSN:  1875-5607     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratorio de Investigación de Productos Naturales. Escuela Superior de Ingeniería Química e Industrias extractivas IPN. Av. Instituto Politécnico Nacional, Unidad Profesional Adolfo Lopez Mateos cp 07758, Mexico D.F. rmpg@prodigy.net.mx.
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