| The alkaloid Ageladine A, originally isolated from marine sponges, used for pH-sensitive imaging of transparent marine animals. | |
| | |
MedLine Citation:
|
PMID: 22363232 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The brominated pyrrole-imidazole Ageladine A was used for live imaging of the jellyfish (jellies) Nausithoe werneri, the sea anemone Metridium senile and the flatworm Macrostomum lignano. The fluorescence properties of Ageladine A allow for estimation of pH values in tissue and organs in living animals. The results showed that Nausithoe werneri had the most acidic areas in the tentacles and close to the mouth (pH 4-6.5), Metridium senile harbours aggregates of high acidity in the tentacles (pH 5) and in Macrostomum lignano, the rhabdoids, the gonads and areas close to the mouth were the most acidic with values down to pH 5. |
| | |
Authors:
|
Ulf Bickmeyer |
Publication Detail:
|
Type: Journal Article Date: 2012-01-19 |
Journal Detail:
|
Title: Marine drugs Volume: 10 ISSN: 1660-3397 ISO Abbreviation: Mar Drugs Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-02-24 Completed Date: 2012-06-29 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 101213729 Medline TA: Mar Drugs Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 223-33 Citation Subset: IM |
Affiliation:
|
Alfred Wegener Institute for Polar and Marine Research in the Helmholtz Society, Am Handelshafen 12, 27570 Bremerhaven, Germany. Ulf.Bickmeyer@awi.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Hydrogen-Ion Concentration Platyhelminths / metabolism* Porifera / chemistry* Pyrroles / diagnostic use* Scyphozoa / metabolism* Sea Anemones / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Ageladine A; 0/Pyrroles |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bioactive hydroperoxyl cembranoids from the Red Sea soft coral Sarcophyton glaucum.
Next Document: Antibacterial bisabolane-type sesquiterpenoids from the sponge-derived fungus Aspergillus sp.