Document Detail

The alkaloid Ageladine A, originally isolated from marine sponges, used for pH-sensitive imaging of transparent marine animals.
MedLine Citation:
PMID:  22363232     Owner:  NLM     Status:  MEDLINE    
The brominated pyrrole-imidazole Ageladine A was used for live imaging of the jellyfish (jellies) Nausithoe werneri, the sea anemone Metridium senile and the flatworm Macrostomum lignano. The fluorescence properties of Ageladine A allow for estimation of pH values in tissue and organs in living animals. The results showed that Nausithoe werneri had the most acidic areas in the tentacles and close to the mouth (pH 4-6.5), Metridium senile harbours aggregates of high acidity in the tentacles (pH 5) and in Macrostomum lignano, the rhabdoids, the gonads and areas close to the mouth were the most acidic with values down to pH 5.
Ulf Bickmeyer
Publication Detail:
Type:  Journal Article     Date:  2012-01-19
Journal Detail:
Title:  Marine drugs     Volume:  10     ISSN:  1660-3397     ISO Abbreviation:  Mar Drugs     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-24     Completed Date:  2012-06-29     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101213729     Medline TA:  Mar Drugs     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  223-33     Citation Subset:  IM    
Alfred Wegener Institute for Polar and Marine Research in the Helmholtz Society, Am Handelshafen 12, 27570 Bremerhaven, Germany.
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MeSH Terms
Hydrogen-Ion Concentration
Platyhelminths / metabolism*
Porifera / chemistry*
Pyrroles / diagnostic use*
Scyphozoa / metabolism*
Sea Anemones / metabolism*
Reg. No./Substance:
0/Ageladine A; 0/Pyrroles

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