Document Detail


Alkaline phosphatase and tartrate-resistant acid phosphatase in osteoblasts of normal and pathologic bone.
MedLine Citation:
PMID:  11729947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A review of histochemical and immunohistochemical studies on alkaline phosphatase (AP) and tartrate-resistant acid phosphatase (TRAP) in osteoblasts leads to the following conclusions: 1) AP is a typical (non-specific) marker of osteoblasts, and TRAP is a typical (non-specific) marker of osteoclasts; 2) both enzymes may be used to identify the precursors of these cells and are found in young osteocytes; 3) both are released into the extracellular space; 4) both are expressed by metaphyseal osteoblast-like cells whose ultrastructural characteristics are similar to those of post-osteoclastic cells of the basic multicellular unit (BMU) and are also exhibited by osteoblasts and macrophages; 5) the increased numbers of these cells in hypocalcemic animals suggests that the local calcium ion concentration may trigger the transition of the reversal into the formation phase of the BMU.
Authors:
E Bonucci; A Nanci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia     Volume:  106     ISSN:  1122-6714     ISO Abbreviation:  Ital J Anat Embryol     Publication Date:  2001  
Date Detail:
Created Date:  2001-12-03     Completed Date:  2002-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9612303     Medline TA:  Ital J Anat Embryol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Affiliation:
Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy. ermanno.bonucci@uniroma1.it
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MeSH Terms
Descriptor/Qualifier:
Acid Phosphatase / metabolism*
Alkaline Phosphatase / metabolism*
Animals
Bone and Bones / enzymology*,  pathology,  ultrastructure
Calcium / deficiency
Calcium Signaling / physiology
Cell Differentiation / physiology*
Humans
Isoenzymes / metabolism*
Osteoblasts / enzymology*,  pathology,  ultrastructure
Osteoclasts / enzymology*,  pathology,  ultrastructure
Stem Cells / enzymology*,  pathology,  ultrastructure
Chemical
Reg. No./Substance:
0/Isoenzymes; 7440-70-2/Calcium; EC 3.1.3.-/tartrate-resistant acid phosphatase; EC 3.1.3.1/Alkaline Phosphatase; EC 3.1.3.2/Acid Phosphatase

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