Document Detail

Alkaline phosphatase and tartrate-resistant acid phosphatase in osteoblasts of normal and pathologic bone.
MedLine Citation:
PMID:  11729947     Owner:  NLM     Status:  MEDLINE    
A review of histochemical and immunohistochemical studies on alkaline phosphatase (AP) and tartrate-resistant acid phosphatase (TRAP) in osteoblasts leads to the following conclusions: 1) AP is a typical (non-specific) marker of osteoblasts, and TRAP is a typical (non-specific) marker of osteoclasts; 2) both enzymes may be used to identify the precursors of these cells and are found in young osteocytes; 3) both are released into the extracellular space; 4) both are expressed by metaphyseal osteoblast-like cells whose ultrastructural characteristics are similar to those of post-osteoclastic cells of the basic multicellular unit (BMU) and are also exhibited by osteoblasts and macrophages; 5) the increased numbers of these cells in hypocalcemic animals suggests that the local calcium ion concentration may trigger the transition of the reversal into the formation phase of the BMU.
E Bonucci; A Nanci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia     Volume:  106     ISSN:  1122-6714     ISO Abbreviation:  Ital J Anat Embryol     Publication Date:  2001  
Date Detail:
Created Date:  2001-12-03     Completed Date:  2002-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9612303     Medline TA:  Ital J Anat Embryol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy.
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MeSH Terms
Acid Phosphatase / metabolism*
Alkaline Phosphatase / metabolism*
Bone and Bones / enzymology*,  pathology,  ultrastructure
Calcium / deficiency
Calcium Signaling / physiology
Cell Differentiation / physiology*
Isoenzymes / metabolism*
Osteoblasts / enzymology*,  pathology,  ultrastructure
Osteoclasts / enzymology*,  pathology,  ultrastructure
Stem Cells / enzymology*,  pathology,  ultrastructure
Reg. No./Substance:
0/Isoenzymes; 7440-70-2/Calcium; EC 3.1.3.-/tartrate-resistant acid phosphatase; EC Phosphatase; EC Phosphatase

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