| Alkaline phosphatase normalization is associated with better prognosis in primary sclerosing cholangitis. | |
| | |
MedLine Citation:
|
PMID: 21251891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Primary sclerosing cholangitis results in elevated but fluctuating serum alkaline phosphatase levels that occasionally return to normal. AIMS: To investigate the frequency of normalization of alkaline phosphatase in newly diagnosed primary sclerosing cholangitis patients and the subsequent clinical outcomes. METHODS: Records of newly diagnosed primary sclerosing cholangitis patients were examined retrospectively for laboratory values and clinical end points (cholangiocarcinoma, liver transplantation and death) within 10 years of diagnosis. Data from a recent prospective ursodeoxycholic acid treatment trial were also studied. RESULTS: Eighty-seven patients met the inclusion criteria. Normalization of alkaline phosphatase was seen in 35 (40%) patients. Five (14%) patients with normalization reached an end point whereas 17 (33%) of the patients with persistent elevation reached an end point (P = 0.02). Ursodeoxycholic acid was used similarly by both groups. When the investigative criteria were applied to a prospective trial, there was again a significant relationship between normalization of alkaline phosphatase and survival in patients receiving ursodeoxycholic acid (P < 0.01) and the placebo group (P = 0.02). CONCLUSIONS: Serum alkaline phosphatase was found to normalize in a high proportion of newly diagnosed primary sclerosing cholangitis patients. This was significantly associated with a better prognosis in a retrospective cohort and when data from a prospective treatment trial was evaluated. |
| | |
Authors:
|
Peter P Stanich; Einar Björnsson; Andrea A Gossard; Felicity Enders; Roberta Jorgensen; Keith D Lindor |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-01-19 |
Journal Detail:
|
Title: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Volume: 43 ISSN: 1878-3562 ISO Abbreviation: Dig Liver Dis Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-03-07 Completed Date: 2011-07-27 Revised Date: 2012-09-19 |
Medline Journal Info:
|
Nlm Unique ID: 100958385 Medline TA: Dig Liver Dis Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 309-13 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Medicine, Mayo Clinic, Rochester, MN 55901, United States. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alkaline Phosphatase / blood* Biological Markers / blood* Cholangitis, Sclerosing / drug therapy, enzymology Female Humans Kaplan-Meier Estimate Male Middle Aged Prognosis Proportional Hazards Models Prospective Studies Reference Values Retrospective Studies Survival Rate Ursodeoxycholic Acid / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
|
DK56924/DK/NIDDK NIH HHS; R01 DK056924-10/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 128-13-2/Ursodeoxycholic Acid; EC 3.1.3.1/Alkaline Phosphatase |
| Comments/Corrections | |
Comment In:
|
Dig Liver Dis. 2011 Apr;43(4):268-9
[PMID:
21345755
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Determination of sulphasalazine and its main metabolite sulphapyridine and 5-aminosalicylic acid in ...
Next Document: The pseudomeningocoele that wasn't: Case report of an adult who presented with a late infection of a...