| Alkaline phosphatase histochemistry in human germ cell neoplasms. | |
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MedLine Citation:
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PMID: 6191586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alkaline phosphatase is a useful and reliable marker of germ cell neoplasia that has been almost completely overlooked in the recent medical literature and in the practice of surgical pathology. Its presence in immature germ cells and in germ cell cancers was noted as early as 1953, but a systematic study of its use in the diagnosis and classification of germ cell tumors has not appeared in the literature. Using a recently developed plastic embedding technique combined with enzyme histochemistry, a large series of germ cell tumors and gonadal specimens were examined for the presence of alkaline phosphatase. The neoplastic germ cells in all cases of seminoma and embryonal carcinoma showed strong plasma membrane positivity for alkaline phosphatase. Choriocarcinomas (gestational and nongestational) and mature teratomas were negative. These findings suggest that the alkaline phosphatase reaction is a useful adjunct in the diagnosis of germ cell cancers. |
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Authors:
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J H Beckstead |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of surgical pathology Volume: 7 ISSN: 0147-5185 ISO Abbreviation: Am. J. Surg. Pathol. Publication Date: 1983 Jun |
Date Detail:
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Created Date: 1983-08-11 Completed Date: 1983-08-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7707904 Medline TA: Am J Surg Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 341-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alkaline Phosphatase / analysis* Cell Membrane / enzymology Choriocarcinoma / enzymology Dysgerminoma / enzymology Female Fetus Histocytochemistry Humans Male Neoplasms, Germ Cell and Embryonal / diagnosis, enzymology* Placenta Diseases / enzymology Pregnancy Staining and Labeling Teratoma / enzymology Testicular Neoplasms / enzymology Uterine Neoplasms / enzymology |
| Grant Support | |
ID/Acronym/Agency:
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CA-14264-09/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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