Document Detail

Alkaline phosphatase histochemistry in human germ cell neoplasms.
MedLine Citation:
PMID:  6191586     Owner:  NLM     Status:  MEDLINE    
Alkaline phosphatase is a useful and reliable marker of germ cell neoplasia that has been almost completely overlooked in the recent medical literature and in the practice of surgical pathology. Its presence in immature germ cells and in germ cell cancers was noted as early as 1953, but a systematic study of its use in the diagnosis and classification of germ cell tumors has not appeared in the literature. Using a recently developed plastic embedding technique combined with enzyme histochemistry, a large series of germ cell tumors and gonadal specimens were examined for the presence of alkaline phosphatase. The neoplastic germ cells in all cases of seminoma and embryonal carcinoma showed strong plasma membrane positivity for alkaline phosphatase. Choriocarcinomas (gestational and nongestational) and mature teratomas were negative. These findings suggest that the alkaline phosphatase reaction is a useful adjunct in the diagnosis of germ cell cancers.
J H Beckstead
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  7     ISSN:  0147-5185     ISO Abbreviation:  Am. J. Surg. Pathol.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  341-9     Citation Subset:  IM    
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MeSH Terms
Alkaline Phosphatase / analysis*
Cell Membrane / enzymology
Choriocarcinoma / enzymology
Dysgerminoma / enzymology
Neoplasms, Germ Cell and Embryonal / diagnosis,  enzymology*
Placenta Diseases / enzymology
Staining and Labeling
Teratoma / enzymology
Testicular Neoplasms / enzymology
Uterine Neoplasms / enzymology
Grant Support
CA-14264-09/CA/NCI NIH HHS
Reg. No./Substance:
EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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