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ALKALINE PHOSPHATASE (ALP) VARIATION DURING CARFILZOMIB TREATMENT IS ASSOCIATED TO BEST RESPONSE IN MULTIPLE MYELOMA PATIENTS.
MedLine Citation:
PMID:  21477075     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The ubiquitin-proteasome pathway regulates bone formation through osteoblast differentiation. We analyzed variation Alkaline Phosphatase (ALP) during carfilzomib treatment. Data from 38 patients enrolled in the PX-171-003 and 29 patients in PX-171-004 studies, for relapsed/refractory myeloma patients, were analyzed. All patients received 20 mg/m(2) of carfilzomib on Days 1, 2, 8, 9, 15, and 16 of a 28-day cycle. Sixty seven patients from ALP data were evaluable. In PX-171-003 the ORR (>PR) was 18% and the clinical benefit response (CBR; >MR) was 26%, while in PX-171-004 the ORR was 35.5% overall and 57% in bortezomib naive patients. ALP increment from baseline was statistically different in patients who achieved ≥VGPR compared to all others on Days 1 (P=0.0049) and 8 (P=0.006) of Cycle 2. In patients achieving a VGPR or better, ALP increased more than 15 units per liter at Cycle 2 Day 1 over baseline. An ALP increase over the same period of time was seen in 26%, 13%, and 11% of patients achieving PR, MR, and SD, respectively. This retrospective analysis of relapsed or refractory myeloma patients treated with single agent carfilzomib indicates that early elevation in ALP is associated with subsequent myeloma response.
Authors:
Maurizio Zangari; Monette Aujay; Fenghuang Zhan; Kristina L Hetherington; Tamara Berno; Ravi Vij; Sundar Jagannath; David Siegel; A Keith Stewart; Luhua Wang; Robert Z Orlowski; Andrew Belch; Andrzej Jakubowiak; George Somlo; Suzanne Trudel; Nizar Bahlis; Sagar Lonial; Seema Singhal; Vishal Kukreti; Guido Tricot
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-7
Journal Detail:
Title:  European journal of haematology     Volume:  -     ISSN:  1600-0609     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
University of Utah, Division of Hematology, Blood/Marrow Transplant and Myeloma Program, Salt Lake City, Utah Stem Cent Rx, LLC University of Padua Italy Washington University, BMT and Leukemia Program, St. Louis, Missouri Mount Sinai Medical Center Hackensack Mayo Scottsdale MD Anderson U Alberta U Michigan City of Hope National Medical Center Princess Margaret Hospital U Calgary Emory Northwestern University.
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