| Aliskiren: a renin inhibitor offering a new approach for the treatment of hypertension. | |
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MedLine Citation:
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PMID: 16989601 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In recent years, the renin-angiotensin-aldosterone system has been shown to be crucial not only in blood pressure haemostasis but also in the evolution of atherosclerosis, which ultimately determines morbidity and mortality. The angiotensin-converting enzyme inhibitors and, recently, the angiotensin receptor blockers (with their low adverse-effect profile) have added a new dimension to the drug treatment of hypertension. Just a decade after the introduction of angiotensin receptor blockers, physicians treating hypertension are now offered another exciting approach to achieving blockade of the renin-angiotensin-aldosterone system through the inhibition of renin. This review outlines the background evidence for aliskiren, the first orally active renin inhibitor. |
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Authors:
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Eoin O'Brien |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Expert opinion on investigational drugs Volume: 15 ISSN: 1744-7658 ISO Abbreviation: Expert Opin Investig Drugs Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-22 Completed Date: 2006-11-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9434197 Medline TA: Expert Opin Investig Drugs Country: England |
Other Details:
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Languages: eng Pagination: 1269-77 Citation Subset: IM |
Affiliation:
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The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. eobrien@iol.ie |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amides Animals Antihypertensive Agents / pharmacology, therapeutic use Drugs, Investigational / pharmacology, therapeutic use* Fumarates / pharmacology, therapeutic use* Humans Hypertension / drug therapy*, metabolism* Renin / antagonists & inhibitors*, chemistry, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Antihypertensive Agents; 0/Drugs, Investigational; 0/Fumarates; 0/aliskiren; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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