| Aliskiren prevents and ameliorates metabolic syndrome in fructose-fed rats. | |
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MedLine Citation:
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PMID: 22291836 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: The renin-angiotensin system plays a major role in the pathogenesis of metabolic syndrome. The objective of this study was to examine the effects of aliskiren, a direct renin inhibitor, on the metabolic syndrome of fructose-fed rats. MATERIAL AND METHODS: Male Sprague-Dawley rats were divided into 4 groups (n = 6 for each group). Group Con: rats were fed a standard chow diet for 8 weeks, group Fru: rats were fed a high fructose diet (60% fructose) for 8 weeks, group FruA: rats were fed a high fructose diet and were co-infused with aliskiren (100 mg/kg/day), and group FruB: rats were treated as group Fru, but aliskiren was administered 4 weeks later. Systolic blood pressure (SBP), homeostasis model assessment-insulin resistance (HOMA-IR), and blood profiles were measured. RESULTS: By the end of week 4 and 8 of a high fructose diet, SBP had increased significantly from 111 ±5 to 142 ±4 and 139 ±5 mmHg (p < 0.05), respectively. A high fructose diet significantly increased HOMA-IR from baseline (6.15 ±1.59) to 21.25 ±2.08 and 21.28 ±3.1 (p < 0.05) at week 4 and 8, respectively, and significantly induced metabolic syndrome. Concurrent aliskiren treatment prevented the development of hypertension and metabolic syndrome in fructose-fed rats. When fructose-induced hypertension was established, subsequent aliskiren treatment for 4 weeks reversed the elevated SBP and ameliorated metabolic syndrome. There were no significant differences in food, water intake, urine flow or body weight gain among groups. CONCLUSIONS: Aliskiren not only prevents but also ameliorates metabolic syndrome in fructose-fed rats. |
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Authors:
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Chu-Lin Chou; Yu-Hsien Lai; Teng-Yi Lin; Tony J F Lee; Te-Chao Fang |
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Publication Detail:
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Type: Journal Article Date: 2011-11-08 |
Journal Detail:
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Title: Archives of medical science : AMS Volume: 7 ISSN: 1896-9151 ISO Abbreviation: Arch Med Sci Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2012-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101258257 Medline TA: Arch Med Sci Country: Poland |
Other Details:
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Languages: eng Pagination: 882-8 Citation Subset: - |
Affiliation:
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Institute of Medical Sciences, Medical College, Tzu-Chi University, Hualien, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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