| Alinidine prevents hypoperfusion-induced transmural flow redistribution in isolated paced rat hearts. | |
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MedLine Citation:
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PMID: 7982277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The effect of alinidine on transmural flow redistribution during hypoperfusion was studied in the isolated rat heart. 2. Low flow perfusion of paced (5 Hz) rat Langendorff preparations with Tyrode's solution for 60 min resulted in loss of left ventricular pressure amplitude and contracture. 3. In the presence of 45.6 mumol/L alinidine in the hypoperfusion medium contractility was maintained and contracture was missing. 4. Myocardial sphere densities were assessed by infusion of fluorescent microspheres after 60 min of hypoperfusion. Histomorphometric evaluation of the left ventricular wall indicated marked redistribution of myocardial flow to the epicardium. Endo/epicardial quotients of sphere densities were significantly greater in alinidine-treated hearts. 5. Perfusion of hearts with 45.6 mumol/L alinidine for 30 min at a pressure of 80 cmH2O decreased coronary flow and contractility, but did not change the transmural quotient of sphere densities. 6. These results show that in isolated rat hearts with a ventricular wall of only 3-4 mm thickness severe hypoperfusion induces a shift in transmural flow distribution which is prevented by alinidine. |
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Authors:
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H Weihs; E Mutschler; A Walland |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 21 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1995-01-03 Completed Date: 1995-01-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 471-6 Citation Subset: IM |
Affiliation:
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Bioferon biochemische Substanzen GmbH and Co., Laupheim, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cardiac Pacing, Artificial Cardiovascular Agents / pharmacology* Clonidine / analogs & derivatives*, pharmacology Coronary Circulation / drug effects* Heart / drug effects, physiology* Male Microspheres Myocardial Contraction / drug effects Rats Rats, Inbred Strains Ventricular Pressure / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 33178-86-8/alinidine; 4205-90-7/Clonidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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