| Alimentary lipemia is enhanced in fiber-fed rats. | |
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MedLine Citation:
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PMID: 9614165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of dietary fiber on the pattern of postprandial lipemia was examined in two studies with male Wistar rats. In the first study, groups of rats were killed after food deprivation (0 h) or 1, 4.5 or 8.5 h after a high fat test meal containing either cellulose (CL) or oat bran (OB). Plasma triglycerides (TG) were higher in the OB group at 4.5 h compared with both the 0-h and the CL-groups at 4. 5 h. In both groups, LDL and TG-rich lipoprotein cholesterol (TRL-C) concentrations were higher at 8.5 h than at 0 h; HDL cholesterol was significantly lower at 8.5 h than at 0 h for the OB group only. The enhanced lipemia when OB was fed may stimulate cholesterol movement from HDL to LDL and TRL. To examine whether TRL secretion rates were responsible for the enhanced lipemia, a second study was conducted. Rats were fitted with jugular catheters and allowed to recover. Two groups were fed either CL or OB and infused with Triton-1339 (400 mg/kg). Two control groups were not fed and were infused with either Triton or saline. Rats were killed 2.5 h after infusion. Plasma TG was 10-fold higher in the Triton group than in the saline group, but did not differ between the OB and CL groups. The relative contribution of TRL-C to total cholesterol was significantly greater in the Triton control than in the OB and CL groups. Enhanced secretion of TRL was not responsible for the lipemia observed in the first study. Rather, alterations in clearance rate were responsible. |
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Authors:
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B Olson; B O Schneeman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of nutrition Volume: 128 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-07-09 Completed Date: 1998-07-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1031-6 Citation Subset: IM |
Affiliation:
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Department of Nutrition, University of California, Davis, CA 95616, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Avena sativa Cellulose / administration & dosage Cholesterol / blood Cholesterol, HDL / blood Dietary Carbohydrates / pharmacology Dietary Fats / pharmacology Dietary Fiber / pharmacology* Food Deprivation / physiology Lipids / blood* Lipoproteins / blood Lipoproteins, LDL / blood Male Polyethylene Glycols / pharmacology Polysaccharides / pharmacology Rats Rats, Wistar Sodium Chloride / pharmacology Time Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Lipids; 0/Lipoproteins; 0/Lipoproteins, LDL; 0/Polyethylene Glycols; 0/Polysaccharides; 0/Triglycerides; 0/lipoprotein cholesterol; 25301-02-4/tyloxapol; 57-88-5/Cholesterol; 7647-14-5/Sodium Chloride; 9004-34-6/Cellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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