Document Detail


Alimentary lipemia is enhanced in fiber-fed rats.
MedLine Citation:
PMID:  9614165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of dietary fiber on the pattern of postprandial lipemia was examined in two studies with male Wistar rats. In the first study, groups of rats were killed after food deprivation (0 h) or 1, 4.5 or 8.5 h after a high fat test meal containing either cellulose (CL) or oat bran (OB). Plasma triglycerides (TG) were higher in the OB group at 4.5 h compared with both the 0-h and the CL-groups at 4. 5 h. In both groups, LDL and TG-rich lipoprotein cholesterol (TRL-C) concentrations were higher at 8.5 h than at 0 h; HDL cholesterol was significantly lower at 8.5 h than at 0 h for the OB group only. The enhanced lipemia when OB was fed may stimulate cholesterol movement from HDL to LDL and TRL. To examine whether TRL secretion rates were responsible for the enhanced lipemia, a second study was conducted. Rats were fitted with jugular catheters and allowed to recover. Two groups were fed either CL or OB and infused with Triton-1339 (400 mg/kg). Two control groups were not fed and were infused with either Triton or saline. Rats were killed 2.5 h after infusion. Plasma TG was 10-fold higher in the Triton group than in the saline group, but did not differ between the OB and CL groups. The relative contribution of TRL-C to total cholesterol was significantly greater in the Triton control than in the OB and CL groups. Enhanced secretion of TRL was not responsible for the lipemia observed in the first study. Rather, alterations in clearance rate were responsible.
Authors:
B Olson; B O Schneeman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  128     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-07-09     Completed Date:  1998-07-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1031-6     Citation Subset:  IM    
Affiliation:
Department of Nutrition, University of California, Davis, CA 95616, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Avena sativa
Cellulose / administration & dosage
Cholesterol / blood
Cholesterol, HDL / blood
Dietary Carbohydrates / pharmacology
Dietary Fats / pharmacology
Dietary Fiber / pharmacology*
Food Deprivation / physiology
Lipids / blood*
Lipoproteins / blood
Lipoproteins, LDL / blood
Male
Polyethylene Glycols / pharmacology
Polysaccharides / pharmacology
Rats
Rats, Wistar
Sodium Chloride / pharmacology
Time Factors
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Lipids; 0/Lipoproteins; 0/Lipoproteins, LDL; 0/Polyethylene Glycols; 0/Polysaccharides; 0/Triglycerides; 0/lipoprotein cholesterol; 25301-02-4/tyloxapol; 57-88-5/Cholesterol; 7647-14-5/Sodium Chloride; 9004-34-6/Cellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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