| Alimentary absorption of gentamicin in preterm infants. | |
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MedLine Citation:
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PMID: 6499348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifty-two preterm neonates receiving oral gentamicin from birth, as prophylaxis against necrotizing enterocolitis (NEC), had serum gentamicin levels measured on the second day of life (52 infants) and on the seventh to tenth days (43 infants). The serum gentamicin concentrations on the second day were 0.5 microgram/ml or less in 21 percent, 0.6 to 1.0 microgram/ml in 15 percent, 1.1 to 2 micrograms/ml in 34 percent, 2.1 to 5 micrograms/ml in 25 percent, and 5 to 7.1 micrograms/ml in 4 percent of the infants. Paired serum gentamicin levels were significantly lower (p less than 0.001) on the seventh to tenth day as compared to the second day. We conclude that preterm infants in the first few days of life absorb orally administered gentamicin. Concomitant use of systemic gentamicin under such circumstances may potentially lead to toxic serum gentamicin concentration. |
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Authors:
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A M Bhat; R G Meny |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical pediatrics Volume: 23 ISSN: 0009-9228 ISO Abbreviation: Clin Pediatr (Phila) Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-01-14 Completed Date: 1985-01-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372606 Medline TA: Clin Pediatr (Phila) Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 683-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Enterocolitis, Pseudomembranous
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prevention & control Gentamicins / blood, metabolism*, therapeutic use Humans Infant, Newborn Infant, Premature* Intestinal Absorption* |
| Chemical | |
Reg. No./Substance:
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0/Gentamicins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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