Document Detail

Aligning Coronary Anatomy and Myocardial Perfusion Territories: An Algorithm for the CORE320 Multicenter Study.
MedLine Citation:
PMID:  22887690     Owner:  NLM     Status:  Publisher    
BACKGROUND: -Appropriate clinical decisions concerning diagnosis and treatment of coronary artery disease rely on correct integration of coronary anatomy and myocardial perfusion data. The purpose of this manuscript is to introduce a new left ventricular segmentation model for improved alignment of coronary arterial segments and myocardial perfusion territories, designed for the CORE320 study. METHODS AND RESULTS: -CORE320 is a prospective, multicenter study with a primary objective to evaluate the diagnostic accuracy of 320-row detector computed tomography to detect coronary artery luminal stenosis and corresponding myocardial perfusion deficits in patients with suspected CAD compared with the gold standard of conventional coronary angiography and single photon emission computed tomography myocardial perfusion imaging. We describe a 19 coronary segment and 13 myocardial territory alignment model, its application in both standard and CT image datasets and the adjudication process of the initial cohort of patients recruited for the CORE320 study. Adjudication committees reviewed the images of the first 101 gold standard and 107 CT datasets. Based on the presented model and rules, all cases for adjudication were correctly identified. During image review, 6 (5.9%) gold standard and 9 (8.4%) CT datasets needed further realignment not triggered by the algorithm. CONCLUSIONS: -We present a vascular territory distribution model developed for the CORE320 multicenter study which accounts for variability in coronary anatomy and potential myocardial perfusion territory overlap. Clinical Trial Registration-URL: Unique identifier: NCT00934037.
Rodrigo J Cerci; Armin Arbab-Zadeh; Richard T George; Julie M Miller; Andrea L Vavere; Vishal Mehra; Kihei Yoneyama; John Texter; Courtney Foster; Wei Guo; Christopher Cox; Jeffrey Brinker; Marcelo Di Carli; Joao A C Lima
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-10
Journal Detail:
Title:  Circulation. Cardiovascular imaging     Volume:  -     ISSN:  1942-0080     ISO Abbreviation:  Circ Cardiovasc Imaging     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101479935     Medline TA:  Circ Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Johns Hopkins University, Baltimore, MD;
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  3.0T whole-heart coronary magnetic resonance angiography performed with 32-channel cardiac coils: a ...
Next Document:  A Generic Strategy for Co-Presentation of Heparin-Binding Growth Factors Based on CVD Polymerization...